University of Medical Sciences and Technology

Direct probabilistic IMPT treatment planning with setup and range errors for neuro-oncological patients

Abstract Objective . To show computational feasibility of a previously proposed probabilistic planning approach on a neuro-oncological patient group, we compared probabilistic plans with (automated) robust plans for one patient (group A) that could achieve sufficient clinical tar...

Prevalence of malaria in the United Villages region, Northern Khartoum State, during armed conflict

Malaria remains a major public health concern in sub-Saharan Africa, where under-resourced health systems and environmental conditions continue to facilitate transmission. In Sudan, the situation has been further aggravated by the ongoing armed conflict that began in April 2023,...

Optimal Strategies for Recovering the Healthcare System and Interdependent Infrastructure in the Gaza Strip and Their Impact on Public Health

BACKGROUND: The Gaza Strip's health system has been disrupted by conflict since October 2023, alongside damage to electricity, water, sanitation and transport systems. This study assessed healthcare functionality, infrastructure disruption and public health outcomes, and identifi...

Efficacy and Safety of Sacituzumab Govitecan for Breast Cancer

Objectives: Sacituzumab govitecan (SG), a Trop-2-directed antibody-drug conjugate, has demonstrated clinical activity in HER2-negative breast cancer. Our meta-analysis aimed to evaluate the efficacy and safety of SG compared with standard chemotherapy in patients with breast canc...

Computational identification of isoflavonoids as novel PPAR-γ agonists for the treatment of type 2 diabetes mellitus

Background The management of type 2 diabetes mellitus (T2DM) using peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists is currently limited by the adverse effects of thiazolidinediones (TZDs), such as fluid retention and weight gain. This necessitates the search fo...

Impact of sudanese chewing tobacco toombak on oral bacteria – a culture-based pilot study

Abstract Objective This study investigated the impact of the Sudanese smokeless tobacco Toombak on cultivable oral bacteria, its potential antibacterial properties, and its own microbial composition. Materials and methods Oral swabs from 20 adult male participants, including ten...

Antibiotic susceptibility of genital tract isolates in pregnant women with premature pre-labour rupture of membranes (PPROM) in a low-resource setting

Premature pre - labour rupture of membranes (PPROM) is a significant obstetric complication that contributes to preterm births, maternal infections, and neonatal morbidity. The role of genital tract infections in the etiology of PPROM is well established, yet data on microbial is...