University of Macerata

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

Earnings inequality patterns: A comparative analysis of France, Italy, Portugal and Spain

Abstract In recent decades, inequality has become a central concern in both academic research and policy debate. This paper examines gross individual earnings inequality among employed workers in four European countries – France, Italy, Portugal, and Spain – using EU-SILC microda...

Value, law, and cooperation. The international dimension of Ghino Valenti’s insights

The timing of the revival of studies on Valenti, linked to the hundred years that have passed since his death (1920), has brought to the surface the international dimension of the Marche scholar, even if Italian economists wrote the tributes to Valenti in international journals....

Beyond prostate-specific antigen: ctDNA as an early compass for treatment adaptation in metastatic prostate cancer

In a recent study published in Nature Cancer , Jayaram and colleagues 1 demonstrated that persistent circulating tumor DNA detection during first-line intensified therapy independently predicts poor survival in patients with metastatic castration-sensitive prostate cancer, provid...

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

Evidence to guide the treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with...

Does increased staging complexity influence expert agreement in dental age estimation?

Dental age estimation (DAE) is a well-established procedure in current practice, and it is frequently required in forensic and legal investigations. This study aimed to evaluate the intra- and inter-observer reliability of dental development staging among forensic practitioners u...

Knowledge, attitude, and practice of antifungal resistance and stewardship among pharmacy students in Zambia: a cross-sectional study to inform antifungal stewardship programs

Background Antifungal resistance (AFR) is a growing global health threat, particularly in low- and middle-income countries such as Zambia, where antifungals are often accessed without prescription. Antifungal stewardship (AFS) programs aim to optimise antifungal use, yet limited...

The obsolescence of protected area categories in a polycrisis world

Current global conservation models face significant limitations in addressing the global polycrisis, and the constraints of the International Union for Conservation of Nature protected area (PA) classification system are part of the issue. The principles of the new conservation p...

Agreeable team members wanted: personality configurations of high-performing individuals in global virtual teams

Purpose Although much research has been done on the Big Five personality traits that underpin individual performance in teams, knowledge of the interdependencies of traits for individual performance is rather limited and especially so in the new ordinary workplace represented by...