University of Louisville

Association of Irreversible Electroporation Treatment with Overall Survival in Stage III Pancreatic Ductal Adenocarcinoma: DIRECT Registry Results

Abstract Background Irreversible electroporation (IRE) is used in selected patients with Stage III pancreatic ductal adenocarcinoma (PDAC), but its association with survival relative to standard-of-care (SOC) therapy remains uncertain. Methods This multicenter observational study...

Beyond the label: Long-term outcomes after surgical management of Ebstein anomaly

Ebstein anomaly is a rare congenital malformation of the tricuspid valve and right ventricle characterized by marked heterogeneity in anatomy, physiology, and clinical presentation. This broad phenotypic spectrum strongly influences the natural history of the disease, the timing...

The Ripple Effects of Misattributed Parentage: The Systemic Family Impact of “Not Parent Expected” Discoveries

ABSTRACT Direct‐to‐consumer (DTC) DNA testing has led to a surge in misattributed parentage discoveries, often referred to as “not parent expected” (NPE) events. While prior research has focused primarily on the experiences of those discovering a parent was not as expected, this...

Q-Conditioning and Q-Gating: Metadata-Driven Attention Mechanisms for Medical Vision Transformers

Background: Vision Transformers (ViTs) have demonstrated efficacy in visual recognition tasks through global dependency modeling via self-attention. However, standard ViT architectures lack native mechanisms for integrating external clinical metadata (e.g., patient demographics,...

Timing and trajectory of acute kidney injury predict mortality in alcohol-associated hepatitis: A multinational cohort study.

BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear. METHODS: In this prospective multicenter cohort from the Global AlcHep...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

Patient Risk Factors for Incidental Pathology After Uterovaginal Surgery for Apical Prolapse: Systematic Review and Global Expert Consensus Statements

Abstract Introduction and Hypothesis Uterus preservation is increasingly used for uterovaginal prolapse (U-POP) repair despite ongoing concerns regarding future uterine, cervical, and adnexal pathology. We evaluated incidental pathology rates, associated risk factors, and created...

Can vision-language models estimate patient age? evidence from panoramic radiographs

Abstract Objective To explore the performance and limitations of three vision-language models (VLMs) in estimating chronological age from panoramic radiographs. Materials and Methods A sample of 140 panoramic radiographs from individuals aged 7 to 20 years was uploaded to three V...

A novel deep learning-based approach for liver segmentation from 3D CT images using probabilistic shape guidance

Abstract Accurate liver segmentation is essential for computer-aided diagnosis (CAD) systems, yet it remains challenging due to anatomical variability, indistinct organ boundaries, and tissue intensity variations in both normal and pathological cases. To address these challenges,...

Wildfire-Derived Biomass as a Feedstock for Activated Carbon Production: Characterization, Heavy Metal Adsorption, and Preliminary Environmental and Economic Assessment

Wildfires burned an average of about 7 million acres per year in the United States between 2000 and 2025, more than twice the annual rate of the 1990s. The woody residue left behind is largely unmanaged. At the same time, heavy-metal contamination of drinking water by lead, cadmi...

C3- and C5-deficient murine cells exhibit severe mitochondrial defects, indicating a pivotal, novel role of innate immunity in regulating hematopoiesis at the electron transfer chain level

We recently reported that the functional intracellular complement network, known as the complosome, is expressed in hematopoietic stem/progenitor cells (HSPCs). In our recent work, murine lineage-negative (Lin − ) bone marrow (BM) mononuclear cells (BMMNC) from C3-KO and C5 –/– m...

Oxygenation and perfusion in large vessel occlusion stroke: rethinking periprocedural management in the endovascular era

Acute ischemic stroke remains a leading cause of death and long-term disability worldwide. In patients with large vessel occlusion (LVO), endovascular thrombectomy (EVT) has revolutionized care by achieving high rates of vessel recanalization. However, successful reperfusion does...

Thiol‐yne Click Polymer Platform for Protecting Steerable Neuroendoscope Tools

ABSTRACT Neurosurgical interventions rely increasingly on minimally invasive (MI) approaches, yet most MI surgical tools are rigid and have limited dexterity. Tendon‐actuated continuum robots are an emerging strategy employing a notched body to afford curvilinear motion upon pull...

DWI-FLAIR mismatch versus perfusion-based selection for extended window thrombolysis in acute ischemic stroke: a meta-analysis of randomized controlled trials

To compare efficacy and safety outcomes of DWI–FLAIR mismatch versus CT/MR perfusion-based selection for intravenous thrombolysis (IVT) in extended-window acute ischemic stroke (AIS), we performed a systematic review and meta-analysis of randomized controlled trials enrolling adu...

The power of words in online auctions: how quality rhetoric and vagueness in item listings influence herding bias and wordiness effects

Abstract This study investigates how listing characteristics influence purchasing decisions in online auctions. Specifically, it examines whether an item description’s length (i.e., wordiness) and herding bias affect the likelihood of a successful sale and explores the moderating...

Fostering compassionate caregiving: an evaluation of a certified nursing assistant compassionate care curriculum

Alzheimer’s disease (AD) significantly impairs cognition, behavior, and functional ability, increasing reliance on caregivers, particularly Certified Nursing Assistants (CNAs) in nursing facilities. Despite their central role, CNA training remains largely task-oriented, with limi...

Ambient Alkaline Pretreatment Enables Isoprenol Fermentation from Lignocellulosic Biomass for Sustainable Aviation Fuel Production

Abstract Mitigating aviation’s carbon emissions remains challenging because air travel relies on energy-dense liquid fuels with limited substitutes. Here, we report a fermentation-based bioconversion process for producing isoprenol, a precursor to 1,4-dimethylcyclooctane (DMCO),...

Copper(II)/TBHP-mediated oxidation of isoindolinones and other substrates—effect of air and oxygen

When employed in conjunction with tert-butyl hydroperoxide (TBHP), iron(III) and copper(II)-catalyzed oxidation systems have proven to be effective in transforming isoindolinones to the corresponding phthalimides. Considering both metal-mediated processes, one of the issues that...

Defining fever-related discomfort in children: an international Delphi consensus

Fever is one of the most common symptoms in childhood and a frequent reason for medical consultation. Current guidelines recommend treating fever only when discomfort is present. However, the concept of fever-related discomfort remains poorly defined and inconsistently applied in...

Screen time is differentially related to visual selective attention and visual feature processing across middle childhood

Abstract Increased screen time has been linked to attention difficulties in early childhood, raising concerns among parents and professionals. However, it remains unclear how screen use influences the development of visual attention and visual processing across childhood. In this...