University of Lethbridge

Contemporary Use of Click Chemistry and Energetic Functional Groups: Practical Considerations and Competency Assessment in a Senior Undergraduate Lab

Abstract Students need to learn about the value of energetic functional groups in order to gain competency in an advanced laboratory setting. By introducing a two-part senior undergraduate laboratory experiment focused around energetic functional groups, students garnered respect...

From pathogenesis to non-medical therapy: A review of exploring sensory and multi-sensory stimulation as a non-invasive treatment approach for Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, marked by the accumulation of amyloid-beta plaques, tau pathology, and synaptic dysfunction, ultimately leading to memory loss, cognitive decline, neuropsychiatric symptoms and neuronal degeneration that impair...

Ant brain metabolomics reveals contrasting purine and amine dynamics in a reversible trematode-induced host manipulation

Abstract The neurochemical mechanisms underlying parasite-induced host manipulations remain poorly understood. Formicid ants infected with lancet fluke, Dicrocoelium dendriticum, attach to vegetation with their mandibles during cool conditions, facilitating ingestion by grazing m...

Climate change impacts flowering, pollinator interactions, and seed yield in canola

Insect-mediated pollination is a crucial ecosystem service that significantly contributes to the fertilisation of crop plants. However, as extreme weather events become more frequent with climate change, environmental stressors such as heat waves and drought threaten this mutuali...

331. Growth Performance of Backgrounding Steers Fed a Diet with Continuous or Intermittent Inclusion of Ergot Alkaloids with and Without a Mycotoxin Deactivating Product.

Abstract This study evaluated the effect of feeding a backgrounding diet (60% barley silage:40% concentrate; DM basis) containing ergot alkaloids, with and without a mycotoxin-deactivating product (MDP), on the growth performance of feedlot steers. Crossbred steers (n = 360; 330...

Life-course sociodemographic influences on mobility decline: a comparative qualitative study of older adults’ perspectives in Canada and Nigeria

Abstract Background Mobility is fundamental to healthy ageing and quality of life, as it enables older adults to continue participating in all spheres of life, including social, cultural, civic, spiritual, and economic activities. This study explored and compared the perspectives...

Exploring individual, interpersonal, community, and environmental correlates of active commuting to school among Spanish adolescents: the PACO study

Objectives To identify and analyze the individual, interpersonal, community, and environmental factors associated with active commuting to school (ACS) among Spanish adolescents, and to examine the contribution of correlates from multiple ecological domains to ACS. Methods A tota...

Spatial learning: the birds and the bees do it differently

Western honey bees, Apis mellifera , and rufous hummingbirds, Selasphorus rufus , are both central-place nectar foragers that navigate between patches of flowers. However, little is known about how these very different animals solve the same task. Their shared foraging ecology pr...

When confident eyewitnesses are mistaken: a mixture model account for the confidence-accuracy relationship

An influential claim suggests that highly confident identifications have a very high probability of being accurate when police use scientifically validated best practices for identification procedures. However, there are exceptions. Using simulation data, we demonstrate that when...

Tree-based structural equation model for assessing measurement invariance in patient-reported outcome measures

Evidence of measurement invariance (MI) is essential to ensure that scores based on patient-reported outcome measures (PROMs) are comparable across groups or over time. Conventional methods for evaluating MI in PROMs are mostly group-based methods that require that relevant diffe...

Neuroligin 3 highlights the sexually dimorphic neural substrates of Drosophila social spacing

Abstract In Drosophila melanogaster, Neuroligin 3 (Nlg3) is a postsynaptic membrane protein important for synapse development and social spacing behaviour, and its human orthologs are associated with autism. We localized Nlg3 to three brain structures: the mushroom bodies (MB) ca...

Nothing new under the sun: Agentic AI and the automated, connected catalog

The emergence of agentic AI is an important technology trend, and its implications for technical services librarianship have the potential to be profound. Agentic AI is introduced and distinguished from generative AI through its capacity to pursue goals, coordinate specialized ag...

Rivals, retaliation and replacement brand preferences: ideology shapes consumer responses to misaligned brand activism

While consumer backlash against ideologically misaligned brand activism is common, the broader competitive consequences remain unexplored. This research investigates how political ideology influences consumer defection and subsequent choice of a replacement brand, testing retalia...

Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex

The integration of new information during sleep reshapes cortical representations that support categorical knowledge. Auto-associative attractor network theories predict that reciprocal excitatory connections help form stable categorical attractors, but direct evidence is missing...