University of Iowa Health Care

Association of Irreversible Electroporation Treatment with Overall Survival in Stage III Pancreatic Ductal Adenocarcinoma: DIRECT Registry Results

Abstract Background Irreversible electroporation (IRE) is used in selected patients with Stage III pancreatic ductal adenocarcinoma (PDAC), but its association with survival relative to standard-of-care (SOC) therapy remains uncertain. Methods This multicenter observational study...

Use of Anticoagulation Among Patients With Atrial Fibrillation or Atrial Flutter in the United States

BACKGROUND: Oral anticoagulation (OAC) remains underused in patients with atrial fibrillation or flutter at high risk of ischemic stroke. We aimed to characterize documented OAC prescribing at diagnosis and during 1-year follow-up and identify factors associated with baseline OAC...

Analysis of brain iron deposition in an in vivo model of pediatric autosomal dominant polycystic kidney disease

Polycystic kidney disease (PKD) represents one form of chronic kidney disease (CKD) affecting the pediatric population. CKD in early life has been associated with neurocognitive deficits and disturbances in iron metabolism. Excess iron accumulation may exacerbate inflammatory and...

Maternal Sedentary Behavior and Breast Milk Extracellular Vesicle MicroRNA Across Pregnancy: A Pilot Study

Background/Objectives: Human breast milk (HM) is the gold-standard nutritional source for infants, delivering not only macro- and micronutrients but also bioactive components, including extracellular vesicles (EVs) enriched with microRNAs (miRNAs) that regulate immune, metabolic,...

MR Neurography of Fine-Caliber Nerves: Technical Considerations and Practical Applications

With the advent of high-resolution imaging techniques, advanced fat and vascular suppression methods, and three-dimensional isotropic acquisitions, MR neurography of fine-caliber nerves has become an indispensable tool in assessment of peripheral neuropathies, but successful imag...

Residential proximity to intensive animal agriculture associates with increased prevalence of antimicrobial resistance in homes

BACKGROUND: Antimicrobial resistance (AMR), a global public health threat, affects rural communities disproportionately due to their unique regional exposures, including proximity to animal feeding operations (AFOs), a source of AMR genes. OBJECTIVE: We evaluated residential prox...

Placental Growth Factor Trajectories During Pregnancy and Child ADHD

This cohort study examines whether placental growth factor trajectories during pregnancy differ across trimesters in women whose children later received an attention-deficit/hyperactivity disorder (ADHD) diagnosis.

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

Front-loaded and mixed delivery models in hybrid cardiac rehabilitation: a systematic review and meta-analysis

Traditional centre-based cardiac rehabilitation (CBCR) reduces cardiovascular mortality but suffers from suboptimal participation due to logistical barriers. Hybrid cardiac rehabilitation (Hybrid CR) has emerged as a flexible alternative, yet previous reviews have treated it as a...