University of Insubria

Vaginal formulations selectively target Lactobacillus iners and Candida spp. while preserving Lactobacillus crispatus

Vaginal eubiosis is associated with low bacterial diversity and Lactobacillus crispatus dominance, whereas Lactobacillus iners often persists after antibiotics. We evaluated complementary approaches to inhibit L. iners and Candida spp. while preserving L. crispatus . Carbohydrate...

Overwhelming post-splenectomy Capnocytophaga canimorsus infection complicated by suspected infection-associated secondary thrombotic microangiopathy with a complement-mediated hemolytic uremic syndrome phenotype and extensive tissue necrosis after a dog bite

Capnocytophaga canimorsus is a rare zoonotic pathogen that can cause fulminant sepsis in asplenic patients, including overwhelming post-splenectomy infection after dog bites. Its association with suspected infection-associated secondary thrombotic microangiopathy with a complemen...

Compositional Characterization of an Infant Formula Containing Fresh Whole Cow’s Milk: A Descriptive Comparison with Commercial Infant Formulas

Human milk is universally recognized as theref optimal source of nutrition for infants. However, breastfeeding may not always be possible or may need to be interrupted because of maternal or infant health conditions. In these situations, infant formulas represent an important nut...

Proper solutions of the $1/H$-flow and the Green kernel of the $p$-Laplacian

We show existence and optimal growth estimate for the weak inverse mean curvature flow issuing from a point, on manifolds with certain curvature and isoperimetric conditions. These theorems imply analogous ones for the flow issuing from relatively compact sets. Some of the result...

Equilibrium strategies for constrained time-inconsistent control problems

Abstract This paper addresses the issue of time inconsistency in recursive stochastic control problems, in which the forward state process evolves under the influence of an additional recursive utility system. Through an adaptation of Ekeland’s variational principle, we establish...

Surgical treatment of complex scapular fractures: a single centre prospective observational study

Abstract Background Conservative management is traditionally preferred for scapular fractures, but recent studies suggest that surgical intervention may improve outcomes in selected patients. This study evaluates functional and imaging outcomes, complication rates, and under-repo...

The indolent nature of gastroblastoma. Report of an illustrative case with 28 years of follow-up showing previously unreported immunohistochemical and molecular features

We report the clinical, morphological, ultrastructural, and molecular features of a gastroblastoma diagnosed in a 27-year-old male describing some unreported findings that can help to better understand this very rare tumor. The clinical course lasting 28 years confirms the indole...

Treatment-Induced PD-L1 Dynamics and Temporal Heterogeneity in Locally Advanced and Metastatic Gastroesophageal Cancer—A Systematic Review

Background/Objectives: Standard guidelines for treating locally advanced and metastatic gastroesophageal cancer (GEC) involve combination regimens of chemotherapy and immunotherapy. Patient eligibility for these treatments is primarily guided by the programmed cell death ligand 1...

Active, explorative, and infected: a meta‐analysis of individual variation in behaviour and parasitism

Behavioural variation among individuals strongly influences how individuals interact with their environment and, consequently, their exposure to parasites. Parasite infections, in turn, can alter host behaviour by imposing energetic costs or manipulating hosts to enhance transmis...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

mRNA Vaccines as Novel Immunotherapeutic Approaches in Gastrointestinal Cancers

Messenger RNA vaccines have moved rapidly from the infectious-disease area into oncology. They now represent an attractive therapeutic option for gastrointestinal (GI) cancers. Personalised constructs, designed to elicit tumour-specific T-cell immunity, have shown acceptable safe...

Analysis of healthcare waste management and transition from incineration to sterilisation: the case study of Beira, Mozambique

Purpose Environmentally sound, safe and cost-effective options for the safe treatment of bio-hazardous solid waste (BSW) are currently lacking in low-income contexts (LICs). The purpose of this article is double: to analyse healthcare waste management (HCWM) in Mozambique at a ci...

Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations

Abstract Ampullary somatostatin-producing D-cell neuroendocrine tumors are rare neoplasms that may be associated with type 1 neurofibromatosis. The molecular features of sporadic ampullary somatostatin-producing D-cell neuroendocrine tumors (SAMSOM-NETs) remain poorly characteriz...

Adelmidrol plus hyaluronic acid injections in the management of shoulder impairment due to rotator cuff disease: an exploratory pilot observational retrospective investigation

BACKGROUND: Shoulder disorders are the third most common musculoskeletal presentation in primary care. Injuries to the structures surrounding this joint are closely related to oxidative stress and can lead to rotator cuff (RC) disease, including subacromial impingement syndrome,...

Pallas’s cat at the capital’s gates: persistence in a changing Mongolian landscape

Abstract Small carnivores, such as the Pallas’s cat ( Otocolobus manul ), play important ecological roles but remain poorly studied in many parts of their range, particularly in landscapes undergoing rapid human-induced change. We investigated Pallas’s cat occupancy and activity...

Analysis of Eigenvalue Clustering Leads to Optimal Scaling in Numerical Radiative Transfer

ABSTRACT We consider a multidimensional polychromatic radiative transfer (RT) problem, accounting for scattering processes in a general form, that is, anisotropic (dipole) scattering with partial frequency redistribution. Given a discrete ordinates () discretization, we report th...

Two Americas of Well-Being: Divergent Rural–Urban Patterns of Life Satisfaction and Happiness from 2.6 B Social Media Posts

Abstract Using 2.6 billion geolocated tweets (2014–2022) and a fine-tuned generative language model, we construct county-level indicators of life satisfaction and happiness for the United States. We document an apparent rural–urban paradox : even in unadjusted county-level means,...

HPV DNA negativity following AHCC or nonavalent vaccination or their combination in women with persistent HPV infection without HSIL

Persistent infection with high-risk human papillomavirus (HR-HPV) is a common clinical condition for which no validated systemic antiviral therapy is currently available, and in the absence of high-grade cervical lesions management is generally limited to surveillance. Active Hex...

Towards resilient forest establishment in Europe: functional traits, genetic diversity and multifunctional design

Abstract Forest restoration and afforestation across Europe are accelerating, yet the decision-making processes governing forest establishment remain unevenly examined, especially from a biodiversity perspective. Considering this and the global environmental changes of climate sh...

Episodic super-Eddington accretion as a clue to Overmassive Black Holes in the early Universe

Abstract Early JWST observations are providing growing evidence for a ubiquitous population of accreting supermassive black holes (BHs) at high redshift, many of which appear overmassive compared to the empirically-derived local scaling relation between black hole mass and host g...