University of Hull

Functional Activity of TDP-43: A Direct Biomarker for ALS

TDP-43 dysfunction is a defining feature of amyotrophic lateral sclerosis (ALS), yet no biofluid biomarker directly measures its functional activity. We developed a serum-based homogeneous time-resolved FRET (hTR-FRET) assay that quantifies TDP-43 RNA binding activity using synth...

Stellar Interpretation of Meteoritic Data and PLotting for Everyone (SIMPLE): Isotope Mixing Lines for Six Sets of Core-collapse Supernova Models

Abstract Bulk meteorites and their inclusions exhibit, for many chemical elements, isotopic variability produced by nucleosynthetic events in stars and supernovae before the formation of the Sun. While the exact astrophysical origins of these variations are still a matter of deba...

Does the AMPD1 C34T Polymorphism Influence Physical Performance in Elite Athletes?

Background/Objectives: Adenosine monophosphate deaminase deficiency has been implicated in impaired exercise capacity. We examined whether the AMPD1 C34T (rs17602729) genotype was associated with athlete status and performance in distance runners (DR) and rugby union (RU) athlete...

‘Talk CKD Options’: improving how clinicians communicate treatment options in advanced kidney disease using a conversation analysis-based training intervention

Abstract Background Most older people with kidney failure and multiple co-morbidities must decide between dialysis or conservative kidney management. Dialysis is often presented as the default, despite providing uncertain survival benefits in this population. The Optimising Staff...

Reducing pre-operative delays in urgent cardiac surgery: evidence for waiting-time effect on post-operative length of stay

Abstract Background According to the National Institute of Cardiovascular Outcomes Research (NICOR) report in 2022, the mean waiting time for urgent coronary artery bypass graft (CABG) surgery in the United Kingdom is 10 days, rather than the recommended 7 days. We conducted a se...

Charge‐Redistribution‐Driven Dual‐Single‐Atom Catalysts on MXene for Hydrogen Evolution

ABSTRACT The hydrogen evolution reaction (HER) exhibits pH‐ and electrolyte‐dependent pathways, imposing intrinsic challenges on the development of catalysts that operate efficiently across wide pH conditions and in seawater electrolysis. Here, we report a dual‐single‐atom cataly...