University of Houston

Intra-abdominal Bowel Dilation in Experimental Gastroschisis Is Associated With a Modifiable Transcriptomic Program of Intestinal Dysfunction

OBJECTIVE: To characterize intestinal transcriptional profiles in gastroschisis, their temporal evolution, and response to fetal intervention. SUMMARY BACKGROUND DATA: Gastroschisis causes significant intestinal dysfunction, with intra-abdominal bowel dilation clinically shown to...

Dual Technology Adoption

Technology adoption remains a critical managerial challenge, in general and specifically in service settings. Investments are substantial but often fail to yield the intended benefits due to low usage among frontline employees, customers, and service partners. Existing technology...

Acquired Resistance to the PRMT5 Inhibitor Confers Collateral Sensitivity to MEK Inhibition in MTAP-Null Non-Small Cell Lung Cancer

Abstract Protein arginine methyltransferase 5 (PRMT5) is a synthetic lethal target in methylthioadenosine phosphorylase-deleted (MTAP-null) cancers. Second-generation MTA-cooperative PRMT5 inhibitors preferentially target MTAP-null cells while largely sparing MTAP-wildtype (MTAP-...

Navigating Classical and Nonclassical Realms of Nucleation and Crystallization

Our understanding of the formation and growth of solids from solution has shaped science for centuries. The classical nucleation and crystal growth theories provided a foundational framework, despite their necessary simplifications. Recent nonclassical concepts have challenged th...

Thermalization regimes in a chaotic Tavis-Cummings model

This work investigates the emergent thermalization regimes in a chaotic Tavis–Cummings (TC) model and their implications in quantum spectroscopy. While the TC model is a cornerstone of cavity quantum electrodynamics, traditional treatments often overlook many-body effects that ar...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Protocol of a randomized controlled trial evaluating telehealth delivery of the Brief Alcohol Screening and Intervention for College Students (BASICS) program

This study is a randomized controlled trial evaluating a telehealth version of the Brief Alcohol Screening and Intervention for College Students (BASICS) program as an equally efficacious alternative to the traditional in-person implementation. The study will recruit 600 college...

Mannosylated Spleen-Targeted Lipid Nanoparticles Enable Enhanced mRNA Delivery to Antigen-Presenting Cells

Abstract Targeted delivery of lipid nanoparticles (LNP) to immune organs remains challenging, and here we introduce a mannosylated spleen-targeted LNP (LNP-PAM) that integrates active and endogenous targeting to enhance mRNA delivery to antigen-presenting cells. A mannose-conjuga...

Mapping Natural Disasters Using Social Media Posts with an Encoder-Decoder Model

Abstract. Real-time mapping of social media posts from users in the affected areas during a natural disaster can generate actionable intelligence for disaster response teams. Given the complexities of natural language used in such posts, modern approaches rely on Artificial Intel...

Halophyte-derived bacterial SynComs improve soybean growth under salinity stress

Abstract Rhizosphere microbes with plant growth-promoting (PGP) traits can sustain crop productivity, yet endophyte-derived synthetic communities (SynComs) from hypersaline environments remain underexplored. We hypothesize that halophyte endophyte-derived SynComs improve stress t...

Plants, soil, and coexistence: an alternative approach to modelling plant-soil feedback

Abstract Background and Aims Plant-soil feedback (PSF) affects plant coexistence and diversity. Although the current paradigm provides a direct experimental method to quantify PSF and explains coexistence with varying levels of success, the emphasis on pairwise interactions hinde...