University of Hong Kong - Shenzhen Hospital

Integrated stress signaling pathways promote adaptive reprogramming for chondrocyte survival in Metaphyseal Chondrodysplasia Type Schmid

Abstract Collagen X, encoded by the Col10a1 gene, is expressed specifically by hypertrophic chondrocytes (HCs) in the cartilage. Mutations of the Col10a1 gene in humans, which increase the endoplasmic reticulum (ER) stress in HCs, lead to metaphyseal chondrodysplasia type Schmid...

Orbitocranial resection for treatment of lacrimal gland malignant tumors with intracranial extension

Objectives This study reports our experience with multidisciplinary surgical management of lacrimal gland malignant tumors with intracranial extension using the orbitocranial approach. Methods We reviewed treatment strategies and surgical approaches for lacrimal gland malignant t...

ARID1B promotes DNA end resection via MDC1 and co-transactivation of DNA repair genes with c-MYC in small cell lung cancer

Abstract AT-rich interactive domain-containing protein 1B (ARID1B) has been implicated in DNA damage repair; however, its precise molecular mechanisms and contributions to small cell lung cancer (SCLC) pathogenesis remain incompletely defined. In this study, analysis of clinical...

Establishing gender- and age-specific reference ranges for eight tumor markers in adults based on real-world data from Southern China

Abstract Objectives To establish and validate age- and sex-specific reference intervals (RIs) for eight common tumor markers using large-scale real-world data (RWD) and to compare the performance of five indirect statistical algorithms for RI derivation. Methods This retrospectiv...

Comparison of sevoflurane and propofol on the novel oxygenation index and respiratory mechanics in gynecological laparoscopic surgery: a randomized controlled trial

The novel oxygenation index (NOI), which incorporates mean airway pressure (Pmean) as a key respiratory parameter, is increasingly being investigated for its enhanced ability to reflect patients’ pulmonary function compared to the traditional oxygenation index (OI). This study ai...

PCSK9 inhibitors usage in South China: A Multi-Center Real-World Study

Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are effective for lipid management in high-risk patients with atherosclerotic cardiovascular disease. Their inclusion in China’s National Reimbursement Drug List and the Hong Kong Hospital Authority Drug Formulary...

Kidney Transplant Recipients’ Experiences of Sleep and Coping Strategies: An Interpretative Phenomenological Study

ABSTRACT Objective To explore the lived experiences of sleep disturbances and coping among kidney transplant recipients (KTRs), thereby providing a basis for developing individualized and targeted nursing interventions. Methods A qualitative study using Interpretative Phenomenolo...

Illness Experiences and Supportive Care Needs of Patients With Early‐Onset Colorectal Cancer: A Qualitative Systematic Review

AIMS: To synthesise the holistic illness experiences and supportive care needs of patients with early-onset colorectal cancer across the entire disease trajectory. BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed in indivi...

Cholecystoduodenal Fistula, Gallstone Ileus, and Choledocholithiasis: A Case Report and Literature Review

ABSTRACT Prompt diagnosis using CT is critical in gallstone ileus, as symptoms are often nonspecific. A combined surgical approach—comprising enterolithotomy, cholecystectomy, and fistula repair—effectively addresses both the obstruction and its underlying source, achieving favor...

The efficacy of concurrent chemoradiotherapy with or without nimotuzumab in high‐risk patients with locally advanced head and neck squamous cell carcinoma post‐surgery: A real‐world study

Abstract Purpose Patients with locally advanced head and neck squamous cell carcinoma (LA‐HNSCC) harboring high‐risk pathological features after radical surgery face high recurrence rates. This real‐world study evaluated the efficacy and safety of concurrent chemoradiotherapy (CC...

Transradial versus Transfemoral Access for Intracranial Aneurysm Embolization: A Narrative Review of Safety, Feasibility, and Current Evidence

Endovascular embolization is a cornerstone treatment for intracranial aneurysms, and transfemoral access (TFA) has traditionally been the default vascular route. Transradial access (TRA) is increasingly used in neurointervention because it may reduce clinically important access-s...

Association of lipid-frailty composite indices with cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: evidence from the UK Biobank and CHARLS

Non-traditional lipid indices have been increasingly investigated as predictors of cardiovascular disease (CVD) risk, and frailty reflects cumulative physiological decline. Whether integrating these complementary dimensions improves CVD risk prediction remains unexplored. We aime...

Fragmentomic features of cell-free DNA in human spent blastocyst medium and their potential for non-invasive embryo ploidy assessment

To characterize the fragmentomic features of cell-free DNA (cfDNA) in spent blastocyst medium (SBM) and their association with embryonic chromosomal status. One hundred fifty SBM samples were obtained from 43 preimplantation genetic testing for aneuploidy (PGT-A) cycles in 39 pat...

Primary Care Quality and Revisit Intention Among Hong Kong Older Adults: A Cross-Sectional Study

Background: The healthcare system of Hong Kong is facing a growing burden arising from chronic diseases and patient demands because of the rapid ageing and healthcare workforce shortage. Primary care is widely recognised as the most cost-effective way in improving health of the p...

Optimal liver segments for hepatic steatosis assessment using ultrasound attenuation imaging with MRI-PDFF as the reference standard

This study aims to identify optimal liver segments for hepatic steatosis assessment using UltraSound Attenuation (USAT) imaging, with MRI-proton density fat fraction (PDFF) as the reference standard. The prospective study included 240 patients who received weight loss counseling...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Autophagy in the Regulation of Placental Development: From Trophoblast Differentiation to Metabolic Stress Adaptation

Successful pregnancy depends on precise placental development, where trophoblast differentiation, syncytialization, invasion, and adaptation to metabolic stress are critical. Autophagy, a lysosome-mediated degradation pathway, has emerged as an important regulator of cellular hom...

Integrated proteomic and metabolomic analysis identifies complement activation and metabolic alterations in the serum of patients with idiopathic membranous nephropathy: an exploratory study

Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome in adults, yet its pathogenesis remains incompletely understood. This exploratory study aimed to characterize serum molecular profiles in IMN patients by integrating proteomics and metabolomics analys...

Autophagy-regulating bioactive nanoparticle alleviates MASH via gut–liver axis-mediated mitochondria/cAMP/GLP1 pathway

Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and i...

Accuracy assessment of Chinese large language models in psoriasis management: a multicenter expert evaluation study

Psoriasis patients in China face severe barriers to disease knowledge acquisition and limited access to medical resources, creating an urgent demand for reliable, evidence-based patient education tools. This multicenter expert evaluation study aimed to systematically assess the q...