University of Health Sciences and Pharmacy

Psychosocial interventions for antiretroviral therapy adherence in people living with HIV in West Africa: a scoping review and bibliometric analysis

Human immunodeficiency virus (HIV) compromises the immune system and remains a major cause of morbidity and mortality. While antiretroviral therapy (ART) is accessible to many individuals, inadequate adherence continues to compromise viral suppression, especially in resource-limi...

Discovery and Characterization of Inhibitors of Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5): Targeting the UFMylation Pathway in Cancer and Neurodegenerative Diseases

Abstract UBA5 is the E1 enzyme that initiates UFMylation, a ubiquitin-like modification implicated in proteostasis, neurodegeneration, and cancer. Here, we report a chemical biology approach to interrogate UBA5 function through small-molecule inhibition. We developed a robust hig...