University of Graz

Data-driven construction of an imine reductase library capable of broad-scope reductive amination at equimolar substrate concentrations

Reductive amination catalysed by imine reductases and reductive aminases has emerged as a powerful method for the asymmetric synthesis of chiral amines, yet the generality and practical limitations of these enzymes remain poorly understood. Here, we combine large-scale, iterative...

Reference-free microsatellite instability detection from tumor sequencing using intrasample variability modeling

ABSTRACT Microsatellite instability (MSI) is a key predictive biomarker across multiple tumor types, but current next-generation sequencing (NGS)-based callers oftendependon matched normals, large reference panels, or pretrained machine-learning models, which limits portability a...

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Lipidomics-guided screening of unexplored natural product chemical space provides access to small molecules that globally reprogram cellular lipid profiles. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp. reshapes immune cell lipidomes, shifting them from...

Challenges and opportunities of solar geoengineering for climate governance

Purpose This review characterizes the governance challenges arising from the potential deployment of solar geoengineering. The authors survey existing theoretical models that analyze the strategic incentives such technologies generate. In particular, this study examines the condi...

Impact of imidacloprid on honey bee hypopharyngeal glands at two levels: measurement reliability and laboratory versus field conditions

The use of neonicotinoids has undoubtedly behavioral and physiological effects on bees. This work aimed to ring test the digital measurement of honey bees’ hypopharyngeal glands (HPGs), validate the method against the subjectivity of the assessors, and assess differences in the i...

Mapping Neighborhood Spatial Structure in Traditional Home Gardens Using UAV-Derived 3D Canopy Models

Understanding the spatial structure of tree communities is fundamental for evaluating ecological interactions and management dynamics in agroforestry systems. However, the structural complexity and small spatial scale of traditional agroecosystems often limit the use of conventio...