University of Fukui

Dynamic Clipping Synthesis of Rotaxanes via Siliconate-Forming Reaction from Bis-Catechol, Organotrimethoxysilanes, and Secondary Amines

Abstract This study presents the dynamic clipping synthesis of [2]rotaxanes composed of catechol siliconate ion–containing crown ethers and secondary ammonium ions. These interlocked structures are stabilized through ion–ion interactions and hydrogen bonding. The σ-symmetric rota...

Dual Aberrant Splicing Caused by an Apparently Missense CHD7 Variant, c.5273A>G ( p.Asp1758Gly ), in CHARGE Syndrome

ABSTRACT CHARGE syndrome is a rare congenital disorder primarily attributed to heterozygous pathogenic variants of the CHD7 gene. Most pathogenic CHD7 variants are loss‐of‐function (LoF) variants, whereas the interpretation of missense variants remains challenging in the absence...

DeepLabCut-based automated system reveals diverse temperature tolerance among medaka strains and related Oryzias species

Abstract Temperature is a critical environmental factor influencing the physiology and behavior of ectothermic animals, yet conventional methods for evaluating thermal tolerance in fish rely on subjective manual observation of loss of equilibrium (LOE), limiting experimental thro...

Atypical sensory traits and changes in white matter microstructures connected to the amygdala and hippocampus of the autistic brain

Abstract Aim Autism spectrum disorder (ASD) is characterized by atypical sensory traits. Understanding whether these traits of individuals with ASD are associated with white matter fiber tracts connected to these subcortical structures may be important; however, this relationship...

Lysophosphatidic acid promotes cutaneous wound healing through vascular maturation and fibroblast activation in a murine model

BACKGROUND: Impaired cutaneous wound healing is a major clinical burden, particularly among older individuals and patients with diabetes. Lysophosphatidic acid (LPA) is a bioactive phospholipid with known roles in cell proliferation, migration, and vascular formation; however, it...