University of Florida Health Science Center

Effects of neurokinin receptor antagonists on sleep disturbance in menopausal women: a systematic review and meta-analysis of randomized controlled trials

Importance: Sleep disturbance is a common and burdensome symptom among perimenopausal and postmenopausal women with moderate to severe vasomotor symptoms (VMS). Although neurokinin (NK) receptor antagonists have demonstrated efficacy for reducing VMS, their effects on sleep distu...

Barriers to Reducing Subthreshold Phototherapy for Neonatal Jaundice

OBJECTIVE: In a national, multicenter quality improvement (QI) collaborative to reduce subthreshold inpatient phototherapy, the proportion of subthreshold encounters was high at baseline and remained high after the intervention period. This study aimed to assess why clinicians st...

Global burden of moyamoya syndrome in pediatric sickle cell disease and implications for the neurosurgical workforce: a systematic review

Abstract Objective The aims of the study were twofold: 1) quantify the global burden of pSCD|MMS, and 2) estimate the number of children who warrant specialist evaluation for possible surgical revascularization. Methods A systematic review was conducted following PRISMA guideline...

Evidence-informed trial recruitment planning: an integrative review of infectious disease trials in Africa

Persistent recruitment and retention challenges undermine trial feasibility, particularly in infectious disease trials. While regulatory frameworks like ICH-GCP and WHO-GCP emphasize ethical trial conduct, they provide limited operational guidance. This integrative review aimed t...

Distinguishing Benign from Malignant Small Enhancing Breast Lesions Using Radiomics

Background/Objectives: Small enhancing lesions (often termed foci if lesion ≤ 5 mm) observed on breast magnetic resonance imaging (MRI) pose a persistent challenge. Their clinical relevance and the most effective management strategy remain unclear, often leading to unnecessary bi...

Thrombotic Thrombocytopenic Purpura Causing Multiple Large Vessel Occlusions: A Case Report

Background Thrombotic thrombocytopenic purpura (TTP) is a hematologic disorder characterized by a severe deficiency or absence of the disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 enzyme (ADAMTS13), which is a protease essential for cleaving von Wi...

Comparative evaluation of nephrotoxicity and antibacterial activity of free and liposomal gentamicin in rats: Biochemical, molecular and histopathological analysis

Gentamicin is a widely used aminoglycoside antibiotic; however, its clinical use is limited by dose-dependent nephrotoxicity. Liposomal drug delivery systems may reduce toxicity while preserving antibacterial efficacy. This study aimed to comparatively evaluate the nephrotoxic an...