University of Connecticut

Heisenberg Uncertainty Principle on half spaces and orthants: best constants, optimizers and stability

Abstract Though the sharp Heisenberg Uncertainty Principle has been extensively studied in the entire Euclidean spaces, the counterpart on the half spaces or more general orthants has been missing in the literature. We investigate the sharp Heisenberg Uncertainty Principle on ort...

Paying upfront: successful initial infections protect against severe future infections

Abstract Understanding the consistency with which individual hosts respond to repeated pathogen exposures is crucial for accurately modeling pathogen transmission and eco-evolutionary dynamics. When hosts face repeated pathogen exposures, immune memory is expected to reduce the p...

How Important Is Internal Information Asymmetry for Firm-Level Productivity?

Theoretical research suggests internal information asymmetry (IIA) between top managers and divisional managers can reduce productivity by distorting internal resource allocation. The net effect, however, is unclear because IIA also reflects valuable private information within di...

Nuclear mitochondrial sequences in great ape Telomere-to-Telomere genomes

Mitochondrial sequences have integrated into the nuclear genome since the origin of eukaryotes. Recent insertions that retain homology to extant mitochondrial DNA (mtDNA), termed NUMTs, confound mtDNA sequence analysis. Here, we use great ape Telomere-to-Telomere (T2T) genomes to...

Regimes Matter: Regime-Based Dynamic Asset Allocation Using Neural Networks

We study Merton's optimal portfolio problem in a market responsive to macroeconomic regimes, as characterized by VIX. Instead of solving the traditional Hamilton-Jacobi-Bellman equation, we train an artificial neural network (ANN) to learn the optimal allocation as a feedback fun...

Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity

Abstract Herpes simplex virus-1 (HSV-1) UL12 gene encodes a well-conserved 5’ → 3’ alkaline exonuclease. UL12 collaborates with the HSV single-strand DNA binding protein ICP8 to mediate recombination-dependent replication of viral DNA and is essential for the production of DNA th...

CircularlyPolarized Luminescence in Terbium-Lanmodulin:Disentangling the Effects of Primary Coordination Sphere and ChromophoreGeometry

Abstract The rational design of highly efficient circularly polarized luminescence (CPL) emitters requires a detailed understanding of the mechanisms governing chiroptical metrics. In particular, the ability to deconvolute the contributions from static and dynamic coupling is cri...

Beyond Supply Security: Territorial Service Security for Regional Science in an Age of Compound Shocks

Contemporary regional shocks are no longer experienced primarily as isolated supply interruptions. They are increasingly lived as disruptions to essential services: cooling during heatwaves, mobility during fuel or transit disruptions, digital connectivity during infrastructure f...

Evaluation of fungicides to control Pythium root rot of snapdragon, 2026

Pythium root rot, caused by the pathogen Pythium ultimum, is a destructive disease of snapdragon in greenhouse production. Symptoms include stunting, chlorosis of lower leaves, and wilting. Eventually, plants wilt completely and plant death may occur. This report evaluates the ef...

A “Suture Staple” Knotless Anchor Technique for Fixation of Tibial Tubercle Avulsion Fractures in Pediatric Patients

Abstract Tibial tubercle fractures are rare injuries most commonly seen in the pediatric population; more specifically the adolescent male population towards the end of peak longitudinal growth. Typically, tibial tubercle fractures are fixed with cannulated screws. However, there...

Caregiver Perspectives on Implementation of Discharge Plans for Children With Medical Complexity

OBJECTIVE The quality of discharge processes impacts adverse outcomes post hospitalization for children with medical complexity (CMC). Perspectives of caregivers at risk for communication challenges (eg, non-English speakers, those with limited health literacy, immigrants) on und...

Graded oxidation state calcium phosphate graphene oxide modulates the mechanical and biological behavior of bone matrices

Calcium phosphate graphene (CaPG) is a promising reinforcement for polymeric bone matrices, yet the impact of graphene oxide (GO) oxidation on CaPG chemistry and matrix performance remains unclear. Our previous work demonstrated that 5 wt% CaPG provides optimal mechanical and bio...

CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established coho...

Urbanicity and County-Level Variation in Transitional Housing Placements for Transition-Age Youth in California Foster Care

The decentralized U.S. child welfare system has resulted in significant variation in practices and outcomes across states and counties. Despite growing attention to varying child welfare experiences based on urbanicity, particularly rural child welfare practice concerning younger...

Blowing Leaves in Archaeology—The Multidimensionality of Technological Complexity in Human Origins Research

Abstract Technological complexity has been a continuous trope in archaeological research from its beginnings in the nineteenth century. Based on a concept of unidirectional cultural evolution, archaeological material was ordered along a linear progression from simple to complex....

A Mid-Atlantic Brook Trout ( Salvelinus fontinalis ) genome to advance conservation and comparative genomics

Brook Trout (Salvelinus fontinalis) are experiencing genomic erosion and demographic declines across the southern portion of their native distribution. A regionally representative reference genome is necessary to support conservation genomic initiatives for this species. While Br...

Ability of Adults to Correctly Use Grey Market Peptide Semaglutide GLP-1 Receptor Agonists Acquired Without a Prescription

A legal loophole allows consumers to purchase peptide semaglutide without a prescription, but websites that sell them do not sell supplies or provide guidance. We assessed the ability and confidence of college students at the University of Connecticut and older adults in performi...

Insights for the substance use disorder care continuum: findings from a qualitative study with sexual and gender minority individuals who use methamphetamine

Abstract Background Methamphetamine use continues to disproportionately affect sexual and gender minority (SGM) communities and is associated with physical, mental, and sexual health harms, including heightened HIV vulnerability. While prior epidemic waves have been well document...

Field evaluation of Pix4D viDoc for retaining wall inspections

Reliably accurate documentation of retaining wall conditions is necessary for managing long-term infrastructure health and maintaining public safety. Current visual inspection practices lack the precision and consistency needed to detect early signs of change in a structure. This...

Red Blood Cell Distribution Width Is Associated With Functional Outcomes Following Surgery for Hip Fracture

BACKGROUND: Elevated red blood cell distribution width (RDW) is increasingly found to be associated with adverse health outcomes in older adults. We leveraged a randomized clinical trial that was investigating responses to supervised exercise (EX) with or without a topical testos...