University of Colorado Cancer Center

Delays in breast cancer presentation, diagnosis, and treatment in young women

BACKGROUND: Breast cancer (BC) in young patients is often identified at later stages, which can result in poor prognosis. It is important to investigate the factors influencing care delays and how delays affect outcomes. METHODS: This study included women aged ≤40 years at diagno...

In silico experiments uncover a novel mechanism underlying mutation rate evolution in sexually reproducing populations

Abstract Natural selection is believed to universally work to lower mutation rates (MR) due to the negative impact of mutations on individual fitness. Mutator alleles can be co-selected by genetic linkage with adaptive alleles in asexual organisms. However, sexual reproduction di...

GSTT2 Switches from a Homeostatic Antioxidant to a Cell-Cycle-Coupled Factor in Therapy-Resistant Esophageal Adenocarcinoma

Background/Objectives: Glutathione S-transferase theta 2 (GSTT2) is highly expressed in esophageal tissues from African American (AA) compared with European American (EA) individuals, but its localization, regulation, and relevance to esophageal adenocarcinoma progression remain...

A Phase II Trial Using Grape Seed Extract for Prostate Cancer Patients With Nonmetastatic Prostate‐Specific Antigen Progression After Local Therapy

ABSTRACT Prostate cancer (PCa) is a major cause of cancer‐related death among American men. While androgen deprivation therapy (ADT) is commonly used in the treatment of rising prostate‐specific antigen (PSA) levels after primary therapy, its adverse systemic side effects support...

Menopause in the All of Us Research Program: a descriptive summary of electronic health record and survey response across sociodemographic characteristics

ABSTRACT Objective Menopause is a significant physiological transition with implications for health outcomes (e.g., cardiometabolic), yet gaps remain in understanding the menopause transition, including how menopause timing and type influence health outcomes. Large-scale cohort s...

Extended Follow-Up of Botensilimab Plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer Without Active Liver Metastases

PURPOSE: Microsatellite-stable metastatic colorectal cancer (MSS mCRC) has limited treatment options and responds poorly to conventional immunotherapy. We report extended follow-up results from a fully-enrolled, phase 1b cohort evaluating botensilimab (BOT; Fc-enhanced anti-CTLA-...