University of California, Riverside

Decoding TnsC Filament Assembly in CRISPR-Associated Transposons Using Interpretable Deep Learning and Molecular Simulations

Abstract CRISPR-associated transposons (CASTs) enable programmable DNA integration, yet how the TnsC regulator forms processive filaments on DNA to coordinate RNA-guided transposition in type V-K CAST systems remains unknown. Here, we integrate large-scale molecular simulations,...

Time-dependent divergence in infection risks among patients with multiple sclerosis treated with fumarates versus anti-CD20 monoclonal antibodies

Background: People with multiple sclerosis (pwMS) treated with anti-CD20 monoclonal antibodies have an elevated infection risk, yet long-term comparative data with oral fumarates are limited. Objective: To compare infection incidence, healthcare resource utilization, and relapse...

HMGB1 andHMGB2 Are O 4-Alkylthymidine-BindingProteins

Abstract Exposure to endogenous and exogenous sources of alkylating agents leads to DNA lesions that can impair cell survival and confer genome instability by eliciting mutations during DNA replication and transcription. Among the DNA alkylation adducts, O4-alkylthymidine (O4-alk...

Wavelength Requirements for Life Detection via Reflected Light Spectroscopy of Rocky Exoplanets

Searching for signs of life is a primary goal of the Habitable Worlds Observatory (HWO). However, merely detecting oxygen, methane, or other widely discussed biosignatures is insufficient evidence for a biosphere. In parallel with biosignature detection, exoplanet life detection...

Inclusion of MyAMI-derived Mg ∕ Ca corrections to the marine carbonate system in the cGENIE.cookie Earth system model (v.0.91)

Abstract. The concentrations of the major cations (esp., Ca2+, Mg2+) in Earth's oceans have undergone large-scale fluctuations in the geological past. This is important because the key geochemical properties of the marine environment that underpin the global carbon cycle – the aq...

Changes in Emergency Department Pediatric Readiness, Inpatient Services, and Excess Child Deaths

Importance Emergency department (ED) pediatric readiness and pediatric inpatient services have changed over time in many hospitals, but the impact of these changes on pediatric outcomes is unclear. Objective To evaluate pediatric mortality associated with changes to ED pediatric...

Changes in Outpatient and Telehealth Visits Among Undocumented Patients

Importance Anti-immigration policies in 2025 may influence outpatient care and telehealth among immigrant communities. Understanding visit patterns is essential for health systems leaders to prepare for shifts in health care use and ensure preventive care. Objective To compare ou...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Carbon Nanotube-Based Biosensors for Non-Invasive Biofluid Analysis

Carbon nanotube (CNT)-based biosensors have emerged as promising platforms for non-invasive biofluid analysis because of their high electrical conductivity, large surface area, tunable optical properties, and versatile surface chemistry, enabling miniaturized, flexible sensing de...

Biracial Emerging Adults’ Phenotype and Multiracial Pride Predicting Academic Achievement via Discrimination Experiences

The current study examined how Biracial emerging adults’ phenotype and Multiracial pride were associated with racial discrimination and, in turn, GPA. Participants were 378 Biracial emerging adults. Results indicated that there were gender differences. Among women, Multiracial pr...

Protest and handcuffs: The repressive effect of arrests

How does arresting protesters shape subsequent mobilization? Arrests account for approximately 14% of government responses to protest and differ theoretically from other repressive tactics, yet their effects on future mobilization remain understudied. We argue that arrests raise...