University Of Bristol Dental Hospital

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Children's Rights to the Best Possible Care: Establishing Processes for Data Collection in Routine Care to Address Questions of Intervention Effectiveness for Children With Speech Sound Disorder

PURPOSE: The United Nations Convention of the Rights of the Child (CRC) recognizes that all children have a right to the best possible care, CRC Article 24 (health, water, food, environment). For children with speech sound disorder, this is vital in order to protect their rights...

Where NHS dental access in England is least resilient

Aims Demographic change may affect access to National Health Service (NHS) dentistry unevenly. This study assessed how fixed provider geography performs under population growth, ageing, and deprivation-focused growth. Methods A scenario-based spatial analysis was conducted using...

Life stage shifts in salivary microbiota determinants: a cross-sectional study in twins

Abstract Both host genetics and environmental exposures shape the salivary microbiota; however, the relative contributions of these factors from early life to adulthood remain unclear. To address this, we profiled the salivary microbiota of 3387 twin pairs: 939 infant pairs (9–12...

The 10-year evolution of a dental undergraduate ‘Blended Learning’ suturing programme

Abstract Introduction Undergraduate dental students in the United Kingdom must be competent in intra-oral suturing before graduating. In 2014, a blended learning programme was introduced to enhance suturing teaching. Methods Students first completed an online suturing tutorial. T...

Common variant contributions to neurodevelopmental risk in orofacial clefts

Abstract Background Children with cleft lip and/or palate (CL/P) experience increased rates of neurodevelopmental difficulties, including ADHD, autism spectrum disorder, and educational challenges. While rare neurodevelopmental copy number variants (ND-CNVs) are enriched in this...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

ABSTRACT Aim Drug‐target Mendelian randomisation (MR) studies investigate whether genetically proxied modulation of druggable proteins affects the risk of periodontitis, thereby identifying potential pharmacological targets. Methods A systematic review was conducted following PRI...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...