University of Bradford

Dual targeting of EGFR signaling and microtubule dynamics enhances replication-associated cellular stress and suppresses tumor growth in gefitinib-resistant non-small cell lung cancer

Acquired resistance to epidermal growth factor receptor (EGFR)-targeted therapy remains a major obstacle in the treatment of EGFR-mutant non-small cell lung cancer (NSCLC). This study investigated whether repurposing mebendazole (MBZ), a microtubule-disrupting agent, could restor...

Rapid Oxidation of Sulfur Compounds: An Oscillatory Helical Baffled Reactor and a Nanocatalyst for Enhancing the ODS Process

The production of clean fuel with stringent limits on harmful contaminants is one of the petroleum refinery industry’s main goals for improving environmental conditions and being eco-friendly. Iron oxide (Fe2O3) loading over composite support (γ-Al2O3–TiO2) was synthesized and ev...

Variation of Hammett reaction constant in the accelerated formation of substituted 2,3-diarylquinoxalines in nebuliser microdroplets

The accelerated condensation of a range of 4-substituted-1,2-phenylenediamines [YC 6 H 3 (NH 2 ) 2 ; Y = F, Cl, Br, CH 3 , CH 3 O, CN, CF 3 , CO 2 CH 3 or NO 2 ] and 4,5-disubstituted-1,2-phenylenediamines [Y 2 C 6 H 2 (NH 2 ) 2 ; Y = F, Cl, Br or CH 3 ] with 3,3’- and 4,4’-disub...

Influence of the mentoring relationship between board chairs and women CEOs on firm performance in Australia: a social role perspective

Abstract Underrepresentation of women in CEO and board-chair roles persists despite decades of scholarly effort, posing a major societal concern by depriving societies of the positive contributions of women’s leadership. While existing studies have predominantly investigated boar...

Rolling friction and particle shape as controls on the static angle of repose of a recycled granular sub-base material

Recycled concrete aggregate is the most direct route to reusing construction and demolition waste as structural sub-base fill, yet its DEM contact parameters remain unconstrained. This study verifies a static angle-of-repose pipeline for ATAIR-EDEM framework material M6 and quant...

Future Outlooks for Water Quality Management: Integrating Sustainability, Resilience, and Social Equity

Water quality management is a growing global priority due to increasing pressures from climate change, population growth, urbanisation, industrialisation, agricultural intensification, and emerging contaminants. These challenges threaten freshwater ecosystems, public health, econ...

Quantifying care provided to children and young people with cancer who die: Estimating the costs and key determining factors of NHS secondary care in England

Background Little is known about hospital use, costs, and factors associated with higher costs in end-of-life care for children and young people with cancer who die. Methods This is a retrospective death-outcome defined cohort study. It included 4,247 children and young people ag...

The impact of late diagnosis on health outcomes among women and children in low-income communities in Northern Nigeria: a quantitative feasibility study

Late diagnosis of treatable conditions like severe acute malnutrition, obstetric emergencies, malaria, HIV, and tuberculosis is a critical driver of morbidity, mortality, and catastrophic household expenditure among women and children in Northeastern Nigeria. Borno State bears an...

Factors associated with cognitive impairment in people with diabetes-related foot ulcers: a systematic review

Diabetes-related foot ulcers (DFUs) are common and serious complications of diabetes mellitus, and recent evidence indicates a potential association between DFUs and the development of cognitive impairment. However, no comprehensive review has been conducted to investigate the tr...

Experimental investigation of scour evolution around a vertical-axis tidal turbine under combined wave-current action

Scour around vertical-axis tidal turbine (VATT) foundations can threaten the long-term stability of tidal-stream energy systems. This study experimentally investigates scour evolution around a VATT foundation under combined wave-current action, focusing on the effects of flow int...

‘To read a life, to clothe the bones, to tell a story’: negotiating death and loss through archaeology and creative practice (the Continuing Bonds: Creative Dissemination project)

While death is universal, experiences of dealing with the dead and dying differ vastly, and yet despite the universality of our mortality, death can remain, for many, a difficult and challenging topic of conversation. This paper presents the methods and results of a creative appr...

Comparative Removal of Pharmaceutically Active Compounds Using Membrane Filtration Processes

For the purpose of removing pharmaceutically active chemicals (PhACs) from wastewater, this study experimentally assesses the removal efficiency of four membrane filtration technologies: microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO) usi...

Empowering Wind Energy Output Optimization: Comparative Assessment of Hybrid Artificial Intelligence Models Towards Wind Speed Forecasting Accuracy

Wind power forecasting is essential for the reliable and efficient operation of wind farms based on power grids, which is significantly important for stakeholders like wind farm owners, power pools, and power traders. Wind power prediction is also crucial for optimal power dispat...

Comparing the GP-CORE and WEMWBS Scores as Predictors of Future Mental Health Service Utilisation and Help-Seeking Behaviour Among UK Students in Higher Education

Background The General Population Clinical Outcomes in Routine Evaluation (GP-CORE) and the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) are two instruments often used to measure psychological distress or well-being in student samples. This study aimed to directly compare t...

Racially minoritised workers’ incivility experiences, and consequences within maternity settings: a multimethod longitudinal qualitative exploration

Abstract Background Workplace incivility is a global concern in healthcare, undermining staff wellbeing, organisational functioning and patient safety. In England, despite National Health Service (NHS) commitments to equality and inclusion, racially minoritised staff continue to...

When education sticks: early imprints and sociopreneurship in emerging economies

This study examines how entrepreneurship education and training (EET) influences sociopreneurship in emerging economies. Drawing on dynamic imprinting theory, we argue that EET received at different stages of life leaves imprints of unequal durability, and that the expression of...

Ruins and the hyper-sensorium: embodied spatial engagement and other neurodivergent practices in urban exploration

Urban exploration is a contemporary practice of accessing and documenting abandoned or off-limits places. In these borderlands of modernity, the rules and norms of mainstream society may seem suspended. Previous literature frames such marginal incursions as leisure, play, and sub...