University of Baltimore

Clathrin recruitment and assembly of phosphorylated B cell receptor is impaired in human diffuse large B cell lymphoma

The B cell receptor (BCR) drives the differentiation of naive B cells into activated plasma cells that produce antibodies. The BCR consists of a plasma membrane-bound surface immunoglobulin (sIg) that binds antigens, and two coreceptor subunits CD79A and CD79B. The intracellular...

Isolation of diverse nontuberculous mycobacteria from Hawai’i feral pigs and identification of Mycobacterium abscessus subsp. bolletii

Abstract Background Nontuberculous mycobacteria (NTM) are environmentally acquired opportunistic pathogens that can cause recalcitrant pulmonary disease, particularly in susceptible individuals. Hawai’i has a high incidence of NTM infections, meriting a better understanding of th...

Outcome heterogeneity in CALR ‐mutated myeloproliferative neoplasms

Summary Calreticulin gene ( CALR ) mutations are seen in 25%–30% of myeloproliferative neoplasms (MPNs). We report outcomes and high‐risk genomic signatures in 149 patients with CALR‐mutated MPN. CALR‐mutated essential thrombocythaemia ( n = 106) progressed to myelofibrosis ( n =...

Longitudinal Surgical Modeling of Early Glioblastoma Recurrence Reveals Emergence of Margin-Associated Neural Programs

Glioblastoma (GBM) is a lethal, treatment-resistant brain cancer characterized by diffuse brain invasion, complex neuron-glioma signaling, and cellular, molecular, and spatial heterogeneity. Surgery is the current mainstay of treatment, aimed at maximizing tumor cytoreduction, de...

General Monotonicity

This article employs techniques from convex analysis to present characterizations of (maximal) n-monotonicity, similar to the well-known characterizations of (maximal) monotonicity found in the existing literature. These characterizations are further illustrated through examples

How is Theory Used in English-Language Scholarly Books on Contemporary Graffiti and Street Art? A Content Analysis

This study presents a content analysis of 48 English-language scholarly books on contemporary graffiti and street art published between 1982 and 2025. Each book was coded using a four-category scheme: EXPLICIT (dedicated theoretical framework with named theorists), EMBEDDED (theo...

Telemedicine-based buprenorphine initiation and maintenance in rural jails: a retrospective observational study

The persistent U.S. opioid overdose epidemic disproportionately affects incarcerated populations, who face a severely heightened risk of fatal overdose after release. Providing medications for opioid use disorder (MOUD) in jails significantly reduces post-release death and boosts...

Targeting RAS for Pancreatic Cancer Interception

Multiple strategies to target RAS are now available to treat pancreatic cancer. As pancreatic precancers also have KRAS mutations, these tools hold great promise for cancer interception.

Plain language review: non-invasive screening for metabolic dysfunction–associated steatotic liver disease (MASLD) and metabolic dysfunction–associated steatohepatitis (MASH) in primary care

Plain Language SummaryWhat is this summary about?Metabolic dysfunction–associated steatotic liver disease, or MASLD, and its severe form, metabolic dysfunction–associated steatohepatitis, or MASH, impose significant global burdens on patients and healthcare systems. It is importa...

High-Field Specific Heat and Fundamental Superconducting Properties of the Single-Phase Type-II Superconductor V 3 Si

The specific heat data above the upper critical magnetic field H c2 , the angular dependence of H c2 , and fundamental superconducting parameters were consequently determined. The V 3 Si sample used in this research does not exhibit the structural transition and its high quality...

Development of biphoton entangled light spectroscopy (BELS) using Bell pairs

We introduce Biphoton Entangled Light Spectroscopy (BELS), a quantum spectroscopic technique that employs polarization-entangled Bell pairs and two-photon interference to probe material properties. In BELS, the measured signal arises not from single-photon intensities but from ch...

Flourishing Childhood Frameworks: A Scoping Review

OBJECTIVES: Experiences in early life impact childhood, lifelong flourishing, and overall well-being. Yet a framework to guide promoting and measuring flourishing in early childhood has not emerged. The objective of this study was to identify frameworks and measures related to pr...

Perceptions of and Barriers to Colorectal Cancer Screening Uptake in Underserved Baltimore and Eastern Shore Populations

Colorectal cancer (CRC) remains a leading cause of preventable cancer mortality, with persistent screening disparities in underserved communities. This qualitative study aimed to identify community-specific barriers to CRC screening among two distinct Maryland populations to info...

Combinatorial action of regulatory systems generates colistin heteroresistance

ABSTRACT Heteroresistance is a form of antibiotic resistance in which a minor subpopulation of resistant cells coexists with a majority susceptible population. Colistin heteroresistance is common among Enterobacter cloacae clinical isolates, threatens its utility as a last-line t...

Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation

Oncogenic KRAS and NRAS mutations are common in hematologic malignancies, but how they signal is less well characterized than in carcinomas. To uncover novel RAS biology and potential therapeutic vulnerabilities, we employed a multi-omics screening approach in multiple myeloma to...

Seen, Heard, and Still Missing: Understanding Clinical Trial Nonparticipation Among Women of Color

Purpose: To examine structural, informational, and cultural barriers to clinical trial participation among women of color (WOC), with emphasis on adolescents and young adults (AYAs), through a community-partnered study to illuminate persistent challenges and generate actionable s...

Examining Practice and Payment Gaps in Otolaryngology: Evidence from US Medicare Data

Abstract Objective To assess longitudinal differences in Medicare reimbursement, billing patterns, and service composition among US otolaryngologists. Study Design Retrospective cohort study. Setting Centers for Medicare & Medicaid Services (CMS) Medicare fee‐for‐service database...

Acceptability and Feasibility of a Primary Care Hypoglycemia Prevention Program: A Pilot Study

OBJECTIVE Hypoglycemia, a major cause of morbidity for people with diabetes, is underrecognized in primary care, leading to underuse of risk mitigation strategies. This study reports the development and acceptability/feasibility testing of the Hypoglycemia Prevention Program (HPP...

Reconstitution of lamin assembly on nuclear pore complex-containing membranes

Intermediate filaments called lamins line the metazoan nuclear envelope and organize the nucleus and genome. Unlike actin and microtubules, purified intermediate filament proteins assemble into non-physiological structures, making it difficult to connect lamin functions to their...

Addressing Medical Neglect in Children With Complex Chronic Conditions

In this issue of Pediatrics, Cleveland et al report a cross-sectional analysis of a 2-state, multiyear database of linked child protective services (CPS) and Medicaid claims data to characterize the prevalence and associations of complex chronic condition (CCC) status across CPS...