University of Arizona College of Medicine- Phoenix

Association between handedness and Alzheimer's disease: Results from a large MindCrowd observational study

BackgroundHandedness is tied to the lateralization of brain functions and significantly affects cognitive function and brain activity. Alzheimer's disease (AD) is a progressive brain disorder that leads to declines in memory, thinking skills, and to behavioral changes, which also...

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Intratumoral Immunotherapy—The Future of Treating Merkel Cell Carcinoma?

Merkel cell carcinoma (MCC) represents a rare but highly aggressive neuroendocrine skin cancer with limited systemic therapy options for patients who fail or are ineligible for immune checkpoint inhibitors (ICIs). Intratumoral (IT) immunotherapy has emerged as a promising strateg...

Hemophagocytic Lymphohistiocytosis in Adults: A Retrospective Case Series and Review

Introduction Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome triggered by infections, malignancies, and autoimmune diseases, often mimicking severe sepsis and delaying diagnosis. We present a case series of three patients with HLH from di...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Mild alkaline phosphatase elevation associates with increased mortality and major adverse liver outcomes in MASLD.

BACKGROUND: Alkaline phosphatase (ALP) elevation is commonly observed in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but its clinical implications in MASLD are unclear. We evaluated whether longitudinal patterns of mild ALP elevation are associ...

Broadening The View of Aryl Diazonium Ion Reactivity with Proteins and DNA

Abstract Aryl diazonium ions (ADIs) are well established for their reaction with both proteins and DNA, and yet these reactions have been studied independently without systematic comparison. When electrophilic bioconjugation probes are introduced to environments containing multip...