University of Arizona Cancer Center

Exercise-mobilized donor lymphocytes enhance blinatumomab activity against B-ALL

Abstract Background Donor lymphocyte infusion (DLI) is used to prevent and treat leukemic relapse after allogeneic hematopoietic cell transplantation, although its efficacy against lymphoid malignancies remains limited. Blinatumomab (Blina), a CD3/CD19 bispecific T-cell engager,...

Activation of the endocytosis pathway stratifies subtypes and therapeutic sensitivity in colorectal cancer

Abstract Endocytosis regulates receptor trafficking and signaling, yet its role in colorectal cancer (CRC) remains unclear. We analyzed transcriptomic data from 15,025 CRC tumors to evaluate gene expression in clathrin-mediated endocytosis (CME) and the endosomal sorting complexe...