University of Applied Sciences Upper Austria

Unified down-stream analysis of crosslinking mass spectrometry results with pyXLMS

Abstract Crosslinking mass spectrometry has become the method of choice for the identification of protein-protein interactions and for gaining insight into the structures of proteins in vivo. However, connecting crosslink search engine results with down-stream analysis tools, and...

Transcript- and Protein-Level Preservation and Spatial Reorganization of EMT and Vascular–Mesenchymal Gene Programs (SNAI1, TGFB1, PECAM1, VIM) in Human Fetal Kidneys with Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)

Background/Objectives: Congenital anomalies of the kidney and urinary tract (CAKUT) are a leading cause of pediatric kidney disease. Epithelial–mesenchymal transition (EMT), governed by SNAI1 and TGF-β, and a vascular–mesenchymal program marked by PECAM1 and VIM are central to ne...