University Medical Center Freiburg

Impact of sudanese chewing tobacco toombak on oral bacteria – a culture-based pilot study

Abstract Objective This study investigated the impact of the Sudanese smokeless tobacco Toombak on cultivable oral bacteria, its potential antibacterial properties, and its own microbial composition. Materials and methods Oral swabs from 20 adult male participants, including ten...

Combination therapy of sutimlimab and rituximab can lead to stable remission in autoimmune hemolytic anemia: a case series

Abstract Autoimmune hemolytic anemia (AIHA) is associated with a significant impairment of quality of life for affected patients and can lead to life-threating hemolytic crises. Complement-mediated destruction of antibody-opsonized erythrocytes is a central pathomechanism in many...

Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency

Abstract Common variable immunodeficiency (CVID) is frequently complicated by autoimmune and inflammatory manifestations associated with profound immune dysregulation (CVIDc), including expansion of T-bet high CD21 low B cells (CD21 low B cells). Elevated serum IL-10 levels have...

Outcome after cataract surgery with IOL implantation in adolescents and adults with juvenile idiopathic arthritis (JIA) associated or ANA-positive anterior uveitis

Purpose Cataract surgery in patients with chronic anterior uveitis may be associated with increased risk for complications and poor outcomes. This study analyses visual outcome, uveitis course and complications after cataract surgery with intraocular lens (IOL) implantation in ad...

Incidence and relative risk of negative outcomes of psychological interventions for pediatric posttraumatic stress disorder: a systematic review and meta‐analysis of randomized controlled trials

Background Negative outcomes of psychological treatments for pediatric posttraumatic stress disorder (PTSD) have been underresearched. Although reporting has increased over the years, a comprehensive systematic review and meta‐analysis is lacking. Methods We conducted a preregist...

A new endoscopic device to facilitate argon plasma coagulation treatment: First Multicenter Clinical Experience

Background and study aims: Argon plasma coagulation (APC) is an established ablation technique, but limited by tangential probe orientation. ArgoCap was developed to allow precise, safe, and reproducible APC by visualizing the argon beam, shielding the probe, maintaining a define...

Treatment with Cistus incanus and Rosmarinus officinalis reduces inflammatory processes in an in vitro virus mimicry approach

Acute respiratory viral diseases caused by single-stranded RNA (ssRNA) viruses like influenza A infection occur frequently in all age groups, with significant impact on morbidity and mortality worldwide. The severity and burden of the disease is tightly connected to host inflamma...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

Electrochemical in vivo oxygen sensing on cochlear implants

Abstract Cochlear implants (CIs) are the most frequently implanted neuroprostheses. Despite the clinical success of CIs, the processes actually occurring at the electrodes post-implantation remain unknown, and the majority of research is limited to endpoint analyses. Electrochemi...

Digital workflow for implant-supported restorations in the mandible including reverse scan bodies: a feasibility study

Abstract Background Completely edentulous mandibles present a challenge for accurate intraoral scanning, which can compromise the passive fit of implant-supported restorations. Reverse scan bodies may improve the accuracy of implant position transfer and support a fully digital w...

Using a digital health tool to strengthen community engagement in arboviral disease prevention: an implementation study in Colombia

Abstract Background Arboviral diseases remain major public health problems in Colombia. Mobile applications such as WhatsApp are increasingly being used to support health interventions by improving community engagement and preventive practices. Given its widespread use in Colombi...

Optical Detuning Strategies for Shielded Loop Resonators

ABSTRACT Purpose To compare detuning performance and evaluate power requirements of optical detuning methods and to demonstrate feasibility of an optically‐detuned 4‐channel receive array. Methods Four optical detuning methods were compared in simulations, bench tests, and phanto...

Minced cartilage implantation for cartilage regeneration: a survey of current clinical practices

INTRODUCTION: The objective of this study is to evaluate how minced cartilage implantation (MCI) is currently applied in clinical settings, focusing on the selection criteria, procedural execution, handling of concomitant joint pathologies, and postoperative management. MATERIAL...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...

Repeated Renal Interventions for Renal Cell Carcinoma in von Hippel-Lindau Disease: Long-Term Outcomes

Von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome frequently associated with recurrent renal cell carcinoma (RCC), often requiring multiple renal interventions. Data on the timing and outcomes of repeated renal procedures remain limited. This study aimed to characte...