University Kebangsaan Malaysia Medical Centre

Artificial Intelligence as a Catalyst for Cell-Based Therapies in Retinal Disease

Retinal degenerative diseases, including age-related macular degeneration (AMD), retinitis pigmentosa (RP), and Stargardt disease, represent leading causes of irreversible vision loss worldwide, collectively affecting hundreds of millions of people. Cell-based therapies, particul...

Free Mucosal Grafting Is a Simple Adjunct for Rapid Re‐Epithelization in Septal Perforation Repair

ABSTRACT Objective Mucosal grafting has become more established in rhinology. While it is accepted that free mucosal grafts take to bone and vascularized recipient beds, the use of mucosal grafting on the contralateral side during nasal septal perforation (NSP) repair with vascul...

Audit-Informed Digital Pathways to Rural Ecological Revitalization: A Configurational Governance Framework Applied to 30 Provincial-Level Regions in China (2018–2022)

Rural regions worldwide face intensifying environmental pressures under the global sustainability transition, yet the digital conditions associated with high levels of rural ecological revitalization (RER) remain insufficiently understood. Existing studies largely examine digital...

Acceptability and Willingness to Use the “CaknaStrok” Mobile Health Application and Associated Factors Among Informal Caregivers of Post-Stroke Patients in Malaysia: Protocol for an Explanatory Sequential Mixed-Methods Study

Background: Stroke is the third leading cause of death and a major cause of long-term disability in Malaysia, where the continuity of post-stroke care depends heavily on unpaid, untrained informal family caregivers. These caregivers face a well-documented “discharge cliff,” assum...

Cellular Senescence and Immune Dysregulation in Acute-on-Chronic Liver Failure: A Case Report Integrating Single-Cell and Spatial Transcriptomic Profiling

Background: Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of cirrhosis, systemic inflammation, and high short-term mortality (1). The underlying mechanisms involve a complex interplay between cellular senescence, immune dysregu...

Cellular Senescence and Immune Dysregulation in Acute-on-Chronic Liver Failure: A Case Report Integrating Single-Cell and Spatial Transcriptomic Profiling

Background: Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of cirrhosis, systemic inflammation, and high short-term mortality (1). The underlying mechanisms involve a complex interplay between cellular senescence, immune dysregu...

A decade later: a longitudinal retrospective cohort study of the clinical course of childhood-onset epilepsy in a multi-ethnic tertiary centre

Abstract Background Epilepsy affects a significant proportion of people globally, with many cases beginning in childhood. However, there is a lack of longitudinal studies exploring the long-term outcomes and characteristics of childhood-onset epilepsy into adulthood. This study a...

Crucial role of telomere maintenance-related genes in survival prediction and subtype identification in colorectal cancer

Abstract Telomere maintenance genes are closely related to colorectal cancer (CRC) development and progression. However, the potential influence of telomere maintenance-related genes (TMRGs) on the prognosis of CRC and their clinical relevance remains insufficiently explored. Uti...

A qualitative study on feeding experiences among caregivers of children with cerebral palsy requiring food texture modification

Background and purpose Children with cerebral palsy often experience feeding difficulties that require food texture modification and are highly dependent on their caregivers, which commonly lead to malnutrition. This study aimed to explore caregiver's current practices, perceptio...

Homologous Recombination Deficiency (HRD) and BRCA oncogenic variants in newly diagnosed advanced Epithelial Ovarian Cancer (EOC): first report among multi-ethnic patients

Ovarian cancer patients with homologous recombination deficiencies (HRD) exhibit specific clinical behaviours and improved responses to platinum-based chemotherapy and poly (ADP-ribose) polymerase treatment. HRD-positive patients are characterised by having genomic scar score (GS...

Effects of Tabata training on physical fitness and mental health-related outcomes in children and adolescents: a systematic review and multilevel meta-analysis

Tabata training is a time-efficient form of high-intensity interval training, typically characterized by repeated 20-s bouts of high-intensity exercise interspersed with 10-s recovery periods. Although HIIT has been studied in children and adolescents, the specific effects of Tab...

Social network analysis and exponential random graph modelling of dengue spatiotemporal linkage networks in an urban Malaysian district

Dengue burden is increasingly concentrated in rapidly urbanising Asian cities, yet routine surveillance rarely captures fine-scale residential spatiotemporal co-occurrence. We characterised a case-level linkage network and identified sociodemographic and residential correlates of...

Modified Yoong Ultrasound‐Guided Rotator Interval Injection for Adhesive Capsulitis: A 2‐Year Follow‐Up

OBJECTIVE: Adhesive capsulitis (AC) is characterized by progressive fibrosis of the glenohumeral capsule, with the rotator interval (RI) as a key pathological site. Ultrasound-guided hydrodilation of the RI (Yoong technique) is an established intervention, but traversal of a thic...