University Hospitals of the Ruhr-University of Bochum

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Deep Brain Stimulation Modulates Nucleus Accumbens Theta-Band Power in a Rodent Model of Schizophrenia

Background/Objectives: Deep brain stimulation has proven a powerful treatment option for various neuropsychiatric diseases. In psychiatry, this is particularly relevant for schizophrenia, where up to one third of patients do not respond to current treatment options. To further un...

Delivering the EU Safe Hearts Plan: the essential role of laboratory medicine in cardiovascular health

Abstract The European Union Safe Hearts Plan provides an opportunity to strengthen cardiovascular prevention, early detection, treatment, and monitoring across Europe. This EFLM position paper argues that laboratory medicine must be recognized as a central component of its implem...

A structural cardiac pathway mediates the risk of ischemic heart disease from TyG-related indices: A prospective cohort study

The triglyceride-glucose (TyG) index and its derivatives are surrogate markers of insulin resistance and are closely associated with cardiovascular risk. However, whether and to what extent they are associated with IHD risk through subclinical cardiac remodeling remains unclear....

Optical genome mapping improves structural variant detection and characterization in syndromic and neurogenetic disorders

Abstract Optical Genome Mapping (OGM) offers superior resolution compared to standard diagnostic methods such as karyotyping and FISH, enabling the detection of nearly all types of chromosomal aberrations with non-centromeric breakpoints. This study evaluated OGM’s potential to e...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Process evaluation of the randomized trial—“Care management for older people with cognitive impairment during and after hospitalisation in Germany (intersec-CM)”

Abstract Background Effective care of people with cognitive impairment and their families depends, among other things, on the cooperation of the professionals involved in their care. An effective dementia care management support model for people with dementia and their families f...

Clinical characteristics, treatment patterns, and survival outcomes in ductal prostate cancer: a multicenter retrospective analysis

Abstract Purpose Prostatic ductal adenocarcinoma (PDA) is a rare, aggressive prostate cancer subtype associated with advanced disease and poorer prognosis than acinar adenocarcinoma. Small ductal components influence management and preclude active surveillance. This study analyze...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Measures for intersectional mental healthcare: results from a participatory interview and focus group study with psychosocial counsellors, people with experience of using mental health services and providers

BACKGROUND: Discriminatory practices and barriers to care are increasingly recognised as a significant challenge for mental healthcare institutions. Yet, little research has considered what measures people with experience of using mental health services and mental healthcare serv...

Sensory data-driven classification of complex regional pain syndrome: a multicentre cohort study

BACKGROUND: The underlying pathophysiological mechanisms of complex regional pain syndrome (CRPS) have been under debate in recent years. Previous studies identified mechanistic CRPS subtypes, which were characterised as 'cold' and 'warm' or peripheral and central phenotypes. Our...