University Hospitals Coventry and Warwickshire NHS Trust

Clinical, Patient Experience and Service Outcomes of a Leisure Centre–Based NHS Musculoskeletal Physiotherapy Service: A Service Evaluation

BACKGROUND: Musculoskeletal (MSK) conditions place substantial burden on individuals and healthcare systems, increasing the demand for accessible, community-based care. This service evaluation assessed an NHS MSK physiotherapy pilot delivered in a leisure centre in a socioeconomi...

Surgical Artificial Intelligence Innovation Trends and Regulatory Insights

Objective: To characterise the landscape of surgical artificial intelligence (AI) devices approved by the US Food and Drug Administration (FDA). Background: AI has the potential to improve surgical pathways, offering capability across screening, diagnosis, decision support, and i...

Health utilities in individuals with alpha-1 antitrypsin deficiency with and without COPD from the EARCO registry

Background Data on health utilities in Alpha-1 antitrypsin deficiency (AATD) are scarce. This study aimed to evaluate health-related quality of life (HRQoL) using the EQ-5D in a cohort of AATD Pi*ZZ individuals from the European AATD Research Collaboration (EARCO) registry and to...

Acceptance of Organs From Deceased Donors: Results of a Global Survey.

Background: With <10% of transplantation needs being met, one contributing factor may be the potential subjectivity in transplant specialists' acceptance of organs. Such decisions, if influenced by knowledge and/or comfort gaps, warrant intervention. We assessed knowledge and com...

Mind the Gap: Disparities in Education on Organ Donation and Transplantation-Results of a Global Survey.

Background: Widely accessible education on organ donation and transplantation (ODT) is a tool to reduce waiting lists, as <10% of transplant needs are met (Global Observatory on Donation and Transplantation). We aimed to assess the current state of access to education on ODT worl...

Association Between Genetic Ancestry and Multiple Sclerosis Severity

OBJECTIVE: The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). METHODS: Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyp...

Lateral Tibial Posterior Slope Induces Anterior Tibial Translation While Lateral-Medial Slope Difference Induces Internal Rotation: A Cadaveric Biomechanical Study

Background: Posterior tibial slope (PTS) influences tibiofemoral kinematics and anterior cruciate ligament (ACL) function. While previous studies have evaluated symmetrical slope modifications, the isolated influences of the medial or lateral PTS remain unclear. This study invest...

Extracorporeal Free-Light-Chain Removal in Myeloma Cast Nephropathy: Plasma Exchange and Hemodialysis Strategies in the Era of Effective Antimyeloma Therapy

Renal impairment affects up to half of patients with newly diagnosed multiple myeloma, and roughly 2–4% require dialysis at presentation, most often because of light-chain cast nephropathy. In these patients, renal recovery is associated with the speed and magnitude of serum free...

AI-augmented colorectal cancer MDT concordance modelling: a prospective evaluation of performance, interpretability, and provider-side budget impact

Abstract Purpose Colorectal multidisciplinary teams (MDTs) face increasing workload. We evaluated whether routinely collected colorectal MDT variables could support local MDT concordance modelling, interpretable feature attribution, and provider-side budget impact estimation. Met...

Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review

Purpose Improved survival from critical illness has produced a growing population of intensive care unit (ICU) survivors with new or worsened physical, cognitive, and mental-health impairment, defined as post-intensive care syndrome (PICS), and frequent distress among families/ca...

Exploring the professional nurse advocate role in quality improvement: a qualitative study

Background: the professional nurse advocate (PNA) programme was introduced in 2021 to support nurse wellbeing and resilience after the pandemic through the Advocating for Education Quality Improvement (A-EQUIP) model. However, the impact of PNAs' quality improvement (QI) work rem...

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors

Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline...

Remote STrOke Rehabilitation (ReSTORe): study protocol for a randomised controlled trial

Abstract Background At least one third of long-term stroke survivors living at home experience ongoing (≥6 months) mild to moderate disability including fatigue, low functional capacity, muscle weakness, anxiety, and depression. Health-related quality of life (HRQoL) and societal...

The Concept of Biological Resectability in Pancreatic Ductal Adenocarcinoma — An Updated Narrative Review

Resectability in pancreatic ductal adenocarcinoma (PDAC) has traditionally been defined according to tumor–vessel relationship on cross-sectional imaging. However, anatomical criteria alone fail to identify occult systemic disease and do not reliably predict early postoperative r...

Efficacy of neuromuscular electrical stimulation as a therapy for sarcopenia in people on haemodialysis: study protocol for the STIM-HD randomised controlled trial

Abstract Background Sarcopenia is highly prevalent among adults receiving haemodialysis and is associated with reduced physical function, impaired quality of life, and increased morbidity and mortality. Although structured exercise programmes can improve muscle health, most peopl...