University Hospitals Cleveland Medical Center

Ocular immune-related adverse events with immune checkpoint inhibitors: A retrospective cohort study

Background Immune checkpoint inhibitors (ICIs) are widely used to treat a variety of malignancies. Ocular immune-related adverse events (irAEs) have been increasingly recognized as rare side effects of these medications. Methods We performed a retrospective study of ocular irAEs...

Systemic inflammation, gut microbiome composition, and cognitive performance among older Ugandans with Alzheimer’s disease and related dementias

Systemic inflammation is implicated in neurodegeneration; however, evidence linking circulating inflammatory biomarkers to cognitive decline remains inconsistent, particularly in low- and middle-income countries. High-sensitivity C-reactive protein (hs-CRP) is a standard systemic...

Hypoxia‐inducible factor‐1a (HIF1a) as a context‐dependent integrator of metabolic stress in skeletal muscle

Skeletal muscle experiences large fluctuations in ATP demand and redox state during contraction, ischaemia and chronic disease, requiring rapid adaptations in substrate selection, mitochondrial workload, vascular coupling, regeneration and protein homeostasis. Hypoxia-inducible f...

Infliximab for the Treatment of Immune Checkpoint Inhibitor-Associated Acute Kidney Injury

Rishi R Patel, Katherine E Myers, Matthew M Mirsky, Iris Sheng, Arash Rashidi; Infliximab for the Treatment of Immune Checkpoint Inhibitor-Associated Acute

Two-year outcomes following concomitant ACL and extra-articular ligament reconstruction: a nationwide analysis of over 5,000 patients

PURPOSE: The anterior cruciate ligament (ACL) is the most commonly injured and reconstruction ligament in the United States. Associated injuries are common, oftentimes including components of the extra-articular knee. However, complications following concomitant ACL and extra-art...