University Hospitals Bristol NHS Foundation Trust

Cancer workforce readiness to identify and respond to domestic abuse: A national survey and follow-up interviews

Purpose Domestic abuse (DA) is a highly prevalent public health and health equity issue. We aimed to investigate cancer professionals’ experiences of DA among patients and assess cancer workforce readiness to identify, respond to, and prevent DA.Methods Cross-sectional survey (n...

Cholangioscopy in the diagnostic and therapeutic work-up of intraductal papillary neoplasms of the bile duct: a systematic review and meta-analysis

Background: Intraductal Papillary Neoplasms of the Bile Duct (IPNB) are rare and diagnostically challenging, particularly in assessing invasiveness and intraductal spread. Cholangioscopy offers promise through direct visualization and targeted biopsies. The aim of this study was...

Surgical waiting times in patients with high‐ and low‐risk renal cell carcinoma in England

Objectives To assess to what extent hospitals meet the uniform English National Health Service ‘timely’ treatment standard, what happens after a breach, and determinants of delay for patients with high‐risk renal cell carcinoma (RCC). Patient and Methods Population‐based study us...

A global study of novel agents in paediatric and adolescent relapsed and refractory B-cell non-Hodgkin lymphoma (Glo-BNHL): protocol for an adaptive international platform clinical trial

The second Paediatric Strategy Forum of the international multi-stakeholder organisation, ACCELERATE (Nov-2017), concluded that an international approach to conducting clinical trials in relapsed and refractory paediatric B-cell non-Hodgkin lymphoma (r/r B-NHL) was critical and t...

Early national comparison of robotic versus conventional hip replacements for arthritis using National Joint Registry data: target trial emulation study

Abstract Objectives To evaluate the early comparative effectiveness of robotic versus conventional total hip replacement (THR) in the UK. Design Target trial emulation study. Setting Public and private hospitals using data from the National Joint Registry of England, Wales, North...

Genetic risk factors for postoperative complications after major surgery and shared genetic aetiology with non-postoperative phenotypes

Abstract Background Up to 15% of patients worldwide experience serious postoperative complications after major surgery. We explored the genetic basis of five common postoperative complications and whether they share genetic aetiology with their non-postoperative equivalents. Meth...

Fifteen-minute consultation: the child with early pubic hair

Premature pubarche refers to the early appearance of pubic hair before 8 years of age in girls and 9 years in boys and is most commonly due to premature adrenarche.Premature adrenarche refers to the early appearance of clinical signs of adrenal androgen action, including pubic or...

Macular neovascularisation subtype determines visual consequences of early fibro-atrophic remodelling in neovascular AMD: PRECISE study report 11

Abstract Purpose To evaluate whether baseline well-delineated hyperreflective material (wdHRM) is associated with short-term visual outcome in treatment-naïve neovascular age-related macular degeneration (nAMD), whether this association differs by macular neovascularisation (MNV)...

Invited submission to Reproduction and Fertility for “Evolving Perspectives in Management of Menopause Transition” Series

Abstract Menopause following cancer treatment is an increasingly recognised component of survivorship yet remains under-addressed in clinical care. The aim of this review is to synthesise current evidence on menopause induced by cancer treatment, by bringing together current evid...

The 10-year evolution of a dental undergraduate ‘Blended Learning’ suturing programme

Abstract Introduction Undergraduate dental students in the United Kingdom must be competent in intra-oral suturing before graduating. In 2014, a blended learning programme was introduced to enhance suturing teaching. Methods Students first completed an online suturing tutorial. T...

From questions to impact in spinal muscular atrophy - identifying community-driven research priorities through a multi-stakeholder European initiative

Abstract Background Advances in medicines have transformed the outlook for people living with spinal muscular atrophy (SMA), yet many needs remain unmet. As the scientific and clinical environment evolves, aligning research priorities with the lived experience of patients is incr...

A qualitative exploration of further education college staff perspectives on the challenges and opportunities for using physical activity to support student mental health in England

Abstract Background The increasing prevalence of poor mental health amongst young people is a public health concern, and physical activity (PA) is a potential intervention that has both physical and mental health benefits. While education settings are important contexts for inter...

The burden of suicide by paraquat poisoning in Taiwan (1987–2017): trends, geographic variations, and demographic characteristics

Pesticide self-poisoning accounts for 14%–20% of global suicides. Paraquat, a highly lethal pesticide, is involved in a considerable number of suicides in some countries. This study investigated the burden, trends, geographic variations, and demographic characteristics of pestici...

Patient, surgeon, and institutional variation in dual-mobility component use in primary total hip arthroplasty

Aims The aim of this study was to quantify the contribution of patient-, surgeon-, and institution-level factors to variation in dual-mobility component use in primary total hip arthroplasty (DM-THA) in England. We sought to determine whether current patterns reflect appropriate...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population‐Based Cohort Study Using Clinical Practice Research Datalink Aurum

Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Usi...

‘Talk CKD Options’: improving how clinicians communicate treatment options in advanced kidney disease using a conversation analysis-based training intervention

Abstract Background Most older people with kidney failure and multiple co-morbidities must decide between dialysis or conservative kidney management. Dialysis is often presented as the default, despite providing uncertain survival benefits in this population. The Optimising Staff...

Patterns of practice and paediatric care

The question we raise in this paper is whether the notion of patterns of practice is useful in clinical ethics. The first part of the paper presents the notion of patterns of practice, describing what it reflects (including important themes from the philosophy of practice) and ho...

A qualitative study exploring how an Emergency Medicine leadership programme was received in Ghana

Introduction Emergency Medicine (EM) is a developing specialty in several West African countries, where practitioners are increasingly assuming leadership roles despite limited training. The EM Leaders programme, originally designed for the UK context, offers leadership training...

Effects of maternal and paternal smoking on offspring cardiometabolic risk factors in adulthood: a multi-method intergenerational Mendelian randomization study

Abstract Background Parental smoking has been linked to several adverse offspring cardiometabolic outcomes; however, evidence is conflicting regarding the causal and long-term nature of these associations. Methods We investigated the effects of maternal and paternal smoking, capt...