University Hospitals Bristol and Weston NHS Foundation Trust

Reported outcomes for patients following postoperative periprosthetic femoral fractures

Aims: Postoperative periprosthetic femoral fracture (POPFF) is an increasingly common and morbid complication of arthroplasty. This review aims to determine what outcomes are reported for POPFF and how they are measured, to inform the development of a core outcome set. Methods: S...

Development of a complex intervention to optimise pre-operative healthcare and early recovery for people having knee or hip replacement: My Knee/Hip Plan

Abstract Background Approximately 250,000 total hip and knee replacements were performed in the UK in 2024. One in five patients who have a knee replacement and one in seven who have a hip replacement are dissatisfied with their outcome and/or have chronic pain after surgery. Som...

From questions to impact in spinal muscular atrophy - identifying community-driven research priorities through a multi-stakeholder European initiative

Abstract Background Advances in medicines have transformed the outlook for people living with spinal muscular atrophy (SMA), yet many needs remain unmet. As the scientific and clinical environment evolves, aligning research priorities with the lived experience of patients is incr...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population‐Based Cohort Study Using Clinical Practice Research Datalink Aurum

Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Usi...

A qualitative study exploring how an Emergency Medicine leadership programme was received in Ghana

Introduction Emergency Medicine (EM) is a developing specialty in several West African countries, where practitioners are increasingly assuming leadership roles despite limited training. The EM Leaders programme, originally designed for the UK context, offers leadership training...