University Hospital Southampton NHS Foundation Trust

RNA sequencing significantly improves HYDIN diagnosis and defines the effects of common deletions in primary ciliary dyskinesia

Abstract Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder affecting ~1:7500 individuals characterised by recurrent chronic respiratory infections, bronchiectasis, laterality defects, and infertility. While at least 60 PCD-causing genes are reported, approximately 30% o...

The next generation of maternal vaccines: scientific advances, regulatory readiness, and strategic planning in Europe

With the recent approval of maternal RSV vaccines and late-phase trials underway for a GBS vaccine, Europe is entering a new era of maternal immunisation. Yet scientific progress is outpacing pregnancy-specific evidence and preparedness for equitable implementation. Pregnant wome...

Generalisability of an adult-trained AI model to paediatric coeliac disease diagnosis: a multicentre external validation study

Background Coeliac disease diagnosis on duodenal biopsies is limited by interobserver variability. We have previously demonstrated pathologist-level performance with our artificial intelligence (AI) model for the histopathological diagnosis of adult coeliac disease, but not in pa...

Surgical waiting times in patients with high‐ and low‐risk renal cell carcinoma in England

Objectives To assess to what extent hospitals meet the uniform English National Health Service ‘timely’ treatment standard, what happens after a breach, and determinants of delay for patients with high‐risk renal cell carcinoma (RCC). Patient and Methods Population‐based study us...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Anti-fibrillarin Positive Systemic Sclerosis Presenting With Myositis and Perimyocarditis

A 45-year-old man with no significant past medical history presented with six months of progressive proximal muscle weakness, inflammatory arthralgia, and functional decline, on a background of two years of progressive depigmented pruritic skin lesions.Examination demonstrated wi...

Uncovering lung virome signatures of COPD severity and acute exacerbations in longitudinally sampled AERIS cohort

Chronic Obstructive Pulmonary Disease (COPD) is increasingly recognized as a complex disorder in which microbial communities may modulate disease progression and exacerbation risk. We investigated the contribution of the respiratory virome to disease severity and acute exacerbati...

Protocolised analgosedation in mechanically ventilated adult patients: A scoping review

Purpose Our objectives were to assess structure and content of analgosedation protocols used for mechanically ventilated adult patients, including those receiving extracorporeal membrane oxygenation (ECMO), against current international sedation guidelines, and to explore reporte...

Predicting the Unpredictable: Development and External Validation of the GO SOAR Surgical Risk Calculator for Data-Driven Predictions of Surgical Complications in Gynaecological Oncology Surgery

Background/Objectives: Universal surgical risk calculators are not validated for use and poorly predict postoperative morbidity and mortality for women undergoing gynaecological oncology surgery. This adversely affects communication of risk resulting in poorly informed decisions...

Thermophysiological and perceptual responses to exercise heat stress in people with cystic fibrosis on Elexacaftor/Tezacaftor/Ivacaftor

Abstract The objective of this study was to investigate thermophysiological and perceptual responses to exercise heat stress in people with cystic fibrosis (pwCF) on Elexacaftor/Tezacaftor/Ivacaftor (ETI) versus healthy controls, and to explore their lived experiences of heat str...

Effects of hyperoxia on pulmonary inflammation and organ injury in a human in vivo model (HIPI): a randomised controlled trial

Introduction It is uncertain whether hyperoxia contributes to adverse intensive care unit outcomes. Potential harm is likely mediated by oxidative stress driving pulmonary and systemic inflammation. Methods We conducted a randomised, double-blind, placebo-controlled trial to test...

A pathobiologic classification of aortic stenosis: Moving beyond the degenerative–bicuspid–rheumatic paradigm

BackgroundAortic stenosis is traditionally categorised as degenerative calcific, congenital bicuspid, or rheumatic. Contemporary molecular biology, multimodality imaging, and transcatheter valve therapy demonstrate that aortic stenosis represents a spectrum of mechanistically dis...

Interventions to reduce diabetes-related distress among adults with type 1 and type 2 diabetes: protocol for a systematic review and meta-analysis

Diabetes distress (DD) refers to the emotional and psychological burden experienced by individuals living with diabetes. Randomized controlled trials (RCTs) have investigated the efficacy of interventions on DD among adults with type 1 diabetes or type 2 diabetes. We aimed to sys...

Beyond the Operating Room? Cytology-Based Yield and Resource Utilization of Outpatient Versus Operating Room EBUS-TBNA Pathways

Background/Objectives: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can be performed via pathways that differ in anesthesia, setting, airway management, monitoring, recovery, and hospitalization. We compared an outpatient endoscopy suite pathway wi...

Factors for Success and Failure of Allergen Immunotherapy ( AIT ) Trial Design in the Light of Evidence‐Based Medicine: Current Aspects 2026

Allergen immunotherapy (AIT) has been acknowledged as the only disease-modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study res...

Extending eFall risk prediction to working-age adults within mental health and learning disability services: a clinical validation study

Abstract Most fall risk tools are developed for older adults; evidence in working-age populations receiving mental health services is limited. To externally validate the existing eFalls prediction model in working-age adults (18–65 years) within a UK integrated teaching National...