University Hospital Ostrava

A multicenter, prospective – retrospective, epidemiological study in Czech and Slovak minors with spinal muscular atrophy treated with nusinersen

Abstract Background We used the Czech REaDY registry to collect and analyse data of paediatric patients with spinal muscular atrophy (SMA) who received nusinersen for five years. By sharing the results, we aim to increase healthcare professionals’ knowledge about this therapy. Re...

Spinal-Multiple-Myeloma-SEG: A Dual-Energy CT Dataset Extended with Trabecular Bone Segmentation of Lumbar Vertebrae

We present an extension of the publicly available Spinal-Multiple-Myeloma-SEG dataset, a dual-energy CT imaging resource for multiple myeloma research. The purpose of this dataset is to enable voxel-wise analysis of vertebral bone microstructure by adding expert-validated segment...

A metal-dielectric photonic crystal-based glucose sensor with sensitivity enhancement by using 2D materials

Abstract Metal-dielectric photonic crystals (MDPhCs) that support the excitation of Bloch-like surface waves (BLSWs) at the interface of an MDPhC and the adjacent medium (analyte) have emerged as a very promising alternative for sensing gaseous analytes with high sensitivity. In...

Non-invasive detection of obstructive sleep apnea from speech in a limited clinical dataset

Abstract This study investigates non-invasive detection of obstructive sleep apnea (OSA) from daytime speech in a limited polysomnography-labeled clinical cohort. The objective was to evaluate whether speaker-verification-inspired representations can support robust speech-based O...

Clinicopathological Characteristics and Outcomes of Primary Parotid Gland Carcinomas in the Czech Republic: a Multicenter Retrospective Cohort Study of 453 Surgically Treated Patients

Parotid gland carcinomas are rare malignancies with marked histological and biological heterogeneity. Most published evidence is derived from single-center or selected institutional series, whereas comprehensive nationwide epidemiological data remain limited. The aim of this stud...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...