University Hospital Olomouc

Third ventricle width on routine MRI is associated with processing speed in multiple sclerosis: a single-centre retrospective observational study

Abstract Background: Cognitive impairment is common in multiple sclerosis (MS), and slowed information processing is among its most frequent manifestations. Although brain volumetry can quantify atrophy, automated volumetric tools are not universally available in routine practice...

Mucosal Inflammation as a Driver of Gd-IgA1 Production in IgA Nephropathy: Mechanistic Support for Targeted Therapies

Rationale & Objective: Immunoglobulin A nephropathy (IgAN) is characterized by mesangial deposition of immune complexes containing galactose-deficient IgA1 (Gd-IgA1), predominantly with λ light chains and Gd-IgA1 glycans-recognizing antibodies. Disease exacerbations are frequentl...

DNA-encoded Ugi reactions in the organic phase: Lactam synthesis and use of cyclic ketones as scaffold-providing oxo-component

Isocyanide multicomponent reactions such as the Ugi fourcenter reaction are attractive for DNA-encoded library design because they allow for synthesizing diverse peptidomimetic and heterocyclic scaffolds from large numbers of simple and readily available starting materials. DNA a...

Sacituzumab govitecan in heavily pretreated metastatic triple-negative breast cancer: a secondary analysis of the CEBCC-102 real-world cohort

Abstract Background Real-world evidence on sacituzumab govitecan (SG) in heavily pretreated patients with metastatic triple-negative breast cancer (mTNBC) remains limited. This study assessed SG outcomes in a multicentre Central European cohort. Methods This retrospective study i...

Prolonged low-dose intravenous thrombolysis in early recurrent stroke

INTRODUCTION: Treatment of acute ischemic stroke follows well-established guidelines and standards of care. However, the optimal management of ultra-early stroke recurrence remains unclear. We present outcomes of prolonged low-dose intravenous thrombolysis used as rescue therapy...

Changes in self-reported smoking among university hospital employees over two decades: a repeated cross-sectional study

Abstract Background Smoking among hospital employees remains an important public and occupational health concern. Healthcare professionals are particularly relevant because of their role in smoking prevention and cessation. This study compared self-reported smoking prevalence amo...

Preferential antiproliferative activity of an oleandrigenin-derived androstane toward prostate cancer cells

Abstract Cardiac glycosides, traditionally used for heart failure, are increasingly recognized for their anticancer potential. This study evaluated the in vitro antitumor activity of ten cardiac glycoside derivatives on androgen-insensitive (DU-145) and androgen-sensitive (LNCaP)...

Non-invasive detection of obstructive sleep apnea from speech in a limited clinical dataset

Abstract This study investigates non-invasive detection of obstructive sleep apnea (OSA) from daytime speech in a limited polysomnography-labeled clinical cohort. The objective was to evaluate whether speaker-verification-inspired representations can support robust speech-based O...

Clinicopathological Characteristics and Outcomes of Primary Parotid Gland Carcinomas in the Czech Republic: a Multicenter Retrospective Cohort Study of 453 Surgically Treated Patients

Parotid gland carcinomas are rare malignancies with marked histological and biological heterogeneity. Most published evidence is derived from single-center or selected institutional series, whereas comprehensive nationwide epidemiological data remain limited. The aim of this stud...