University Hospital of North Norway

Trends in overweight and obesity in relation to weight change attempts in young adulthood: cross-sectional and repeated measurements from a population-based health study, the Fit Futures study

Abstract Background : Young adulthood is a key period for the development of overweight and obesity; however, less is known about changes in BMI and weight-related behaviors across this life stage. The aim of this study was therefore to examine sex-specific patterns of body mass...

Recommendations for managing multiple long-term conditions: a systemaftic guideline review and modified Delphi study

Recommendations for managing multiple long-term conditions (MLTC) aim to support healthcare professionals in delivering patient-centred, goal-oriented and coordinated care. Previous systematic reviews and consensus studies have informed MLTC management, and new guidance has becom...

Heart rate and blood pressure variability, and baroreflex sensitivity, during heat exposure in persons with type 2 diabetes and hypertension

The autonomic nervous system regulates cardiovascular homeostasis during stressors such as heat, but the effects of type 2 diabetes (T2D) with hypertension on such responses are unclear. Twenty male participants (10 with type 2 diabetes and hypertension and 10 age-matched healthy...

Sex differences in the diabetes-related risk of incident myocardial infarction and relationship to established CHD risk factors. The Tromsø Study (1979-2016)

Abstract Aim To examine whether the adverse effect of diabetes on the risk of incident myocardial infarction (MI) differs between sexes and assess to what extent established coronary heart disease (CHD) risk factors contribute to the elevated risk. Methods Prospective study of 42...

Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease

Importance Nicotinamide riboside, a nicotinamide adenine dinucleotide precursor, has been proposed as a potential disease-modifying therapy for Parkinson disease based on preclinical and early studies. Whether prolonged oral nicotinamide riboside improves clinical outcomes in Par...

Early-onset neonatal sepsis and neonatal antibiotic exposure in Hungary a nationwide population-based study

Abstract Neonatal sepsis remains a challenge in perinatal medicine. We aimed to estimate incidence of culture positive early-onset sepsis (CP-EOS), causative pathogens and overall antibiotic exposure in newborn infants in Hungary. Retrospective national registry analysis (2020–20...

No impact of parity on global gene expression levels in breast cancer tissue and normal breast tissue – a nested case-control study in the Norwegian Women and Cancer study

Abstract Background We have previously demonstrated that the linear decrease in postmenopausal breast cancer incidence with increasing parity is linked to expression changes in hundreds of genes in the peripheral blood cells of healthy women. However, these changes are not observ...

Promotion of long-term health in early life

Noncommunicable chronic diseases (NCDs) are on the rise in high-income countries, leading to substantial morbidity and mortality and contributing to increased resource demands and healthcare costs. Early-life exposures can initiate trajectories that culminate in NCDs later in lif...

The Psychopathology in Autism Checklist–Revised (PAC-R): Development and Validation

There are few appropriate screening tools for mental health in autistic people, particularly for individuals with co-occurring intellectual disabilities. A specially developed screening tool for this population, the Psychopathology in Autism Checklist (PAC), has shown acceptable...

Platelet concentrates in sinus augmentation: The impact of platelet dose and biological characteristics— A systematic review and meta‐analysis

Abstract This systematic review investigated the osteogenic effects of platelet concentrate (PRF/PRP) when combined with non‐autogenous graft materials in sinus lift procedures. Key characteristics assessed included platelet concentration, total platelet dose, leukocyte content,...

CT-based radiological score (AMESI CT-score) for severity of bowel injury in acute mesenteric ischemia

PURPOSE: To evaluate whether common bowel-related CT signs alone can reliably identify irreversible bowel injury in acute mesenteric ischemia (AMI) and to develop a radiological score to enhance reporting and assist clinical decision-making. METHODS: This ancillary analysis of th...