University Hospital of Heraklion

Is Exposure to Certain Endocrine-Disrupting Chemicals Associated with Increased Skin Cancer Risk?

Background/Objectives: This review investigated whether exposure to certain endocrine-disrupting chemicals (EDCs) increases skin cancer risk. Methods: We performed a comprehensive narrative review of in vitro, animal, and human studies examining the association of EDCs with melan...

Complement Signaling and Regulated Cell Death in Immune-Mediated Glomerular Injury

The complement system is a central component of innate immunity, with essential roles in host defense, immune complex clearance, apoptotic cell removal, and tissue homeostasis. In the kidney, glomerular and tubular structures are continuously exposed to circulating and locally pr...

Diagnostic Performance of the Lymphocyte Transformation Test and Patch Testing in Delayed Hypersensitivity Drug Reactions

Background: Cutaneous adverse drug reactions (CADRs) occur in 2–5% of inpatients, primarily due to delayed (T-cell-mediated) reactions, such as maculopapular exanthemas (MPEs). The lymphocyte transformation test (LTT) detects drug-specific T-cell responses with varied sensitivity...

Infectious triggers in IgA vasculitis in children: current evidence, causal attribution and immunopathogenic mechanisms

Abstract IgA vasculitis (IgAV) is the most common systemic vasculitis in childhood. Its seasonal distribution and frequent respiratory or gastrointestinal prodromes implicate environmental exposures. However, microbiological detection temporally proximate to disease onset is insu...

Cause of death in a contemporary cohort of patients with pulmonary arterial hypertension

Abstract Background In pulmonary arterial hypertension (PAH), contemporary risk tools primarily estimate all-cause mortality, offering limited insight into what patients die from. Aims We aimed to characterize causes of death across baseline risk strata and to examine baseline fa...

Illness Coherence, Exercise Adherence, and Patient-Reported Outcomes in Chronic Spinal Pain: A Moderated Mediation Analysis

Background/Objectives: Illness coherence has been associated with treatment engagement and adherence, but its relationship with exercise adherence and patient-reported outcomes in chronic spinal pain remains unclear. This study examined whether unsupervised exercise adherence med...