University Hospital of Geneva

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Performance evaluation of a position-sensitive SiPM-based gamma camera for intraoperative imaging

Abstract Background The POSiCS camera is a handheld and wireless, small field-of-view gamma camera developed for use in radio-guided surgery (RGS), with sentinel lymph node biopsy (SLNB) as its benchmark application. This compact and lightweight detector (about $$350\,\textrm{g}$...

Quantitative MRI Susceptibility: Mapping of Transient Ischemic Attack—A Preliminary Study

A transient ischemic attack (TIA) is a transient episode of neurological dysfunction without evidence of acute infarct demarcation on neuroimaging. The radiographic features of TIAs are uncertain, as since there is currently no perfect imaging method with which to differentiate a...

Robotic-assisted versus conventional laparoscopic rectopexy for rectal prolapse: a single-center cohort study

<title>Abstract</title> Background Minimally invasive techniques have become the standard of care for treating rectal prolapse through a transabdominal approach. However, there is limited data comparing the laparoscopic and robotic approaches in terms of long-term recurrence and...

Community-Associated Methicillin-Resistant Staphylococcus aureus Among Gay, Bisexual, and Other Men Who Have Sex with Men Living with HIV Who Engage in Chemsex in Barcelona, Spain: Epidemiological Patterns and Implications for Infection Control

Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are increasingly reported among gay, bisexual, and other men who have sex with men (GBMSM) engaging in chemsex, yet data remain limited. This ambispective cohort study conducted at H...

Diagnostic Accuracy of Artificial Intelligence Versus Musculoskeletal Radiologists for Foot and Ankle Fracture Detection on Radiographs

Background/Objectives: To evaluate the diagnostic accuracy of a standalone artificial intelligence fracture detection software on foot and ankle radiographs, compared with board-certified musculoskeletal radiologists, with emphasis on midfoot injuries. Materials and Methods: This...

From thunder to silence: Cochlear implantation for bilateral profound sensorineural hearing loss after lightning strike

INTRODUCTION: Lightning strikes can cause diverse neuro-otologic injuries. Tympanic membrane rupture is common, whereas bilateral profound sensorineural hearing loss with vestibular dysfunction and perilymphatic fistula is rare. Cochlear implantation for lightning-induced deafnes...

Beating the Odds: Survival After Extracorporeal Membrane Oxygenation Decannulation Due to Poor Prognosis in Children—An Extracorporeal Life Support Organization Registry Study

Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for critically ill children. However, decisions regarding discontinuation due to poor prognosis remain ethically complex. While outcomes after successful weaning are well described, survival following decann...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...