University Hospital Kralovske Vinohrady

Optimal Depolarization Sequence for CRT Patients

Abstract Background Electrical ventricular dyssynchrony is a hallmark of intraventricular conduction disease in heart failure with reduced ejection fraction. Although cardiac resynchronization therapy (CRT) is effective, a proportion of patients with ECG evidenced electrical dyss...

Sacituzumab govitecan in heavily pretreated metastatic triple-negative breast cancer: a secondary analysis of the CEBCC-102 real-world cohort

Abstract Background Real-world evidence on sacituzumab govitecan (SG) in heavily pretreated patients with metastatic triple-negative breast cancer (mTNBC) remains limited. This study assessed SG outcomes in a multicentre Central European cohort. Methods This retrospective study i...

Nociception monitoring during cardiac surgery with cardiopulmonary bypass: limitations and future directions

Abstract Adequate suppression of nociception remains a fundamental objective of modern cardiac anaesthesia. Interpretation of nociception monitoring during cardiac surgery involving cardiopulmonary bypass (CPB), however, is complicated by profound physiological alterations includ...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Clinicopathological Characteristics and Outcomes of Primary Parotid Gland Carcinomas in the Czech Republic: a Multicenter Retrospective Cohort Study of 453 Surgically Treated Patients

Parotid gland carcinomas are rare malignancies with marked histological and biological heterogeneity. Most published evidence is derived from single-center or selected institutional series, whereas comprehensive nationwide epidemiological data remain limited. The aim of this stud...

Global Prevalence of Keratoconus in the Adult Population: A Systematic Review

To synthesize contemporary estimates of adult keratoconus prevalence worldwide and determine how geography, demographics, and study methodology shape reported rates. We systematically reviewed original studies (2019–2024) quantifying keratoconus in adults. We excluded paediatric-...

Hepatitis A vaccination and its public-health impact in routine prevention and outbreak control: a systematic review and meta-analysis

Background Hepatitis A vaccination is used for routine prevention and outbreak control, but its effectiveness and population-level impact have not been comprehensively synthesised. We aimed to assess vaccine effectiveness, certainty of evidence, and population-level impact. Metho...

Cocaine‐Induced Midline Destructive Lesions: A Historical Review of Diagnostic Mimicry

ABSTRACT Objective To review the historical evolution of cocaine‐induced midline destructive lesions (CIMDL), from cocaine's medical introduction to contemporary diagnostic classification. Data Sources PubMed/MEDLINE, Embase, Scopus and Google Scholar were searched from inception...

Depression in people with epilepsy: reliability and validity of the Czech version of Beck Depression Inventory (BDI-II) and Beck Depression Fast Screen (BDI-FS) for major depressive episode

Objective Depression affects up to 55% of people with epilepsy (PWE) yet remains systematically underdiagnosed. This study aimed to evaluate the psychometric properties of the Czech versions of the Beck Depression Inventory–II (BDI-II) and Beck Depression Inventory–Fast Screen (B...

Towards Personalized Medicine in Chronic Kidney Disease: A Roadmap for the future of Early Detection, Diagnosis, and Management: A Consensus Roadmap from the EUTox, PerMedik and KidneyHealth networks

Chronic kidney disease (CKD) affects more than 800 million individuals worldwide and represents one of the fastest‑growing causes of morbidity and mortality. Despite major therapeutic advances, CKD is frequently detected only after substantial and irreversible loss of kidney func...