University Hospital Kralovske Vinohrady

Global Prevalence of Keratoconus in the Adult Population: A Systematic Review

To synthesize contemporary estimates of adult keratoconus prevalence worldwide and determine how geography, demographics, and study methodology shape reported rates. We systematically reviewed original studies (2019–2024) quantifying keratoconus in adults. We excluded paediatric-...

Hepatitis A vaccination and its public-health impact in routine prevention and outbreak control: a systematic review and meta-analysis

Background Hepatitis A vaccination is used for routine prevention and outbreak control, but its effectiveness and population-level impact have not been comprehensively synthesised. We aimed to assess vaccine effectiveness, certainty of evidence, and population-level impact. Metho...

Cocaine‐Induced Midline Destructive Lesions: A Historical Review of Diagnostic Mimicry

ABSTRACT Objective To review the historical evolution of cocaine‐induced midline destructive lesions (CIMDL), from cocaine's medical introduction to contemporary diagnostic classification. Data Sources PubMed/MEDLINE, Embase, Scopus and Google Scholar were searched from inception...

Depression in people with epilepsy: reliability and validity of the Czech version of Beck Depression Inventory (BDI-II) and Beck Depression Fast Screen (BDI-FS) for major depressive episode

Objective Depression affects up to 55% of people with epilepsy (PWE) yet remains systematically underdiagnosed. This study aimed to evaluate the psychometric properties of the Czech versions of the Beck Depression Inventory–II (BDI-II) and Beck Depression Inventory–Fast Screen (B...

Towards Personalized Medicine in Chronic Kidney Disease: A Roadmap for the future of Early Detection, Diagnosis, and Management: A Consensus Roadmap from the EUTox, PerMedik and KidneyHealth networks

Chronic kidney disease (CKD) affects more than 800 million individuals worldwide and represents one of the fastest‑growing causes of morbidity and mortality. Despite major therapeutic advances, CKD is frequently detected only after substantial and irreversible loss of kidney func...