University Hospital in Motol

SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis

Abstract Purpose Primary salivary gland tumors form a heterogeneous group with diagnostic challenges. Sex-determining region Y-related homeobox 10 (SOX10) is a transcription factor studied in primary salivary gland tumors for over a decade. To date, no systematic review or meta-a...

The Effects of Age on the Presence of Atypical Corneal Nerve Formations

Purpose: The aim of this study was to describe the presence of atypical nerve formations (ANFs, previously termed microneuromas) and their relation to standardized ocular surface parameters and changes in the sub-basal nerve plexus in a group of patients with suspected small fibe...

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

A multicenter, prospective – retrospective, epidemiological study in Czech and Slovak minors with spinal muscular atrophy treated with nusinersen

Abstract Background We used the Czech REaDY registry to collect and analyse data of paediatric patients with spinal muscular atrophy (SMA) who received nusinersen for five years. By sharing the results, we aim to increase healthcare professionals’ knowledge about this therapy. Re...

Cardiovascular Autonomic Neuropathy in Charcot–Marie–Tooth Disease: A Genotype‐Stratified Study of PMP22 Duplication and GJB1 Mutation Carriers

ABSTRACT Background and Aims Data on cardiovascular autonomic neuropathy (CAN) are sparse in Charcot–Marie–Tooth disease. We aimed to determine the prevalence of CAN in CMT1A and CMTX1 and its associations with neuropathy severity and heart rate variability (HRV), compared with a...

Machine learning integrated explainable artificial intelligence in predicting toxicities of enfortumab vedotin in urothelial carcinoma: an exploratory study

Background Enfortumab vedotin (EV) therapy for advanced urothelial carcinoma is limited by adverse events (AEs). Early identification of high-risk patients is needed. This proof-of-concept study evaluated whether machine learning (ML) with explainable AI (SHAP) could predict EV t...

From established biology to candidate archetypes in high-grade serous ovarian carcinoma: the ARCHETYPE-PX evidence framework and consensus method

Background. High-grade serous ovarian carcinoma (HGSOC) causes most deaths from ovarian cancer, and treatment remains largely empirical outside the homologous-recombination-deficient subgroup. Genomic, immune, stromal and treatment-induced states with different therapeutic vulner...

Clinicopathological Characteristics and Outcomes of Primary Parotid Gland Carcinomas in the Czech Republic: a Multicenter Retrospective Cohort Study of 453 Surgically Treated Patients

Parotid gland carcinomas are rare malignancies with marked histological and biological heterogeneity. Most published evidence is derived from single-center or selected institutional series, whereas comprehensive nationwide epidemiological data remain limited. The aim of this stud...

Impact of adpkd-associated PKD1 gene variants on the human facial phenotype quantified by 3d geometric morphometry

Verification and visualization of the possible impact of PKD1 causative variants associated with autosomal dominant polycystic kidney disease (ADPKD) on facial phenotype using three-dimensional (3D) geometric morphometry. Three-dimensional facial scans of 39 adult patients with A...

Depression in people with epilepsy: reliability and validity of the Czech version of Beck Depression Inventory (BDI-II) and Beck Depression Fast Screen (BDI-FS) for major depressive episode

Objective Depression affects up to 55% of people with epilepsy (PWE) yet remains systematically underdiagnosed. This study aimed to evaluate the psychometric properties of the Czech versions of the Beck Depression Inventory–II (BDI-II) and Beck Depression Inventory–Fast Screen (B...

Nonfermenting Gram-Negative Bacilli Other Than Pseudomonas and Acinetobacter Species in Pediatric Blood Cultures: A Multicenter European Analysis

BACKGROUND: Nonfermenting Gram-negative bacilli other than Pseudomonas and Acinetobacter species are increasingly recognized as opportunistic pathogens in pediatric populations, yet their epidemiology and antimicrobial resistance remain poorly defined. METHODS: We conducted a mul...