University Hospital in Halle

Future GLP-1 receptor co-agonists and their cardiac effects

Agonists at glucagon-like-peptide-1 receptors (GLP-1R) are becoming approved drugs to treat not only type 2 diabetes and obesity but also cardiac diseases such as coronary heart disease, myocardial infarction and heart failure. Agonism at the GLP-1R can be combined with agonism a...

Contractile effects of Aficamten in the human atrium

Abstract Aficamten is an approved drug to treat hypertrophic cardiomyopathy. Aficamten desensitizes bovine myofilaments against calcium cations. In isolated animal cardiac preparations, aficamten reduced force of contraction (FOC) but its effects on isolated human cardiac prepara...

Comparison of new and recurring post-acute infection syndrome – results from a German population-based cohort

New respiratory infections after or while experiencing post-acute infectious syndromes (PAIS) can lead to resurgence of symptoms. Data comparing symptoms, related impairment, and duration of first and recurring PAIS episodes are lacking. This cross-sectional study was conducted i...

Views on Ageing and Loneliness in Older Patients Undergoing Geriatric Treatment

Background/Objectives: Loneliness is a clinically relevant psychosocial factor in later life and has been associated with adverse mental, cognitive, and physical health outcomes. Views on ageing may shape social engagement, coping, and perceived belonging, but evidence from geria...

The Proteinase Activated Receptor-2 mediates Protective Immunity in Early Experimental Leishmaniasis

Resistance to Leishmania (L.) major depends on the development of a L. major-specific Th1 response, while Th2 differentiation results in susceptibility. We previously showed that the early microenvironment of infected skin delivers important signals for T cell differentiation. We...

Pediatric Intraosseous Arteriovenous Malformation of the Mandible: A Therapeutic Challenge

Intraosseous arteriovenous malformations (AVMs) of the mandible are rare but potentially life-threatening vascular anomalies in childhood. We report the case of a 7-year-old girl with an initially misdiagnosed (“keratocystic”) lesion who presented with recurrent intraoral bleedin...

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs

BACKGROUND: Survival after pediatric critical illness has improved substantially, but many survivors and their families experience long-term physical, neurocognitive, psychological and social sequelae, summarized as post-intensive care syndrome in pediatrics and in families. Stru...

Gastric Scintigraphy as a Bridge Between Objective and Clinical Evaluation of Delayed Gastric Emptying Following Pancreatic Surgery—A Pilot Study

Introduction: Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy, occurring in up to two-thirds of patients. Although rarely life-threatening, DGE prolongs hospitalization and increases healthcare costs. The International Study Group of Pancreatic...

Medical information and decision-making in palliative cancer: a qualitative study of patients’ perceptions, needs, and preferences regarding physician communication

BACKGROUND: Patients with advanced cancer are frequently confronted with complex treatment decisions in the context of high emotional burden and potential limited prognostic benefit. Physician communication and the provision of medical information are therefore central to informe...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...