University Hospital Hradec Králové

Comparative Analysis of Drop Mass Variance for Manual and Automatic Delivery of Large–Scale Eye Drop Poultry Vaccine

Abstract The delivery of ocular vaccines in the poultry industry is a crucial challenge, where manual eye-drop administration is prone to user-dependent variation. This leads to significant vaccine waste, increased labor costs, and potential health risks to animals. Employing rob...

Machine learning integrated explainable artificial intelligence in predicting toxicities of enfortumab vedotin in urothelial carcinoma: an exploratory study

Background Enfortumab vedotin (EV) therapy for advanced urothelial carcinoma is limited by adverse events (AEs). Early identification of high-risk patients is needed. This proof-of-concept study evaluated whether machine learning (ML) with explainable AI (SHAP) could predict EV t...

Quaternary ammonium compounds: outdated or relevant antiviral agents? A narrative review of QAC efficacy against enveloped and non-enveloped viruses

Quaternary ammonium compounds (QACs) are widely used disinfectants, favored for their broad antimicrobial action and safety profile. However, viral disinfection is complex and affected by multiple variables, including the virus’s envelope status, exposure time, temperature, and o...

Effects of Evolocumab on Mortality Outcomes in Patients Without Previous Myocardial Infarction or Stroke: A Prespecified Analysis of the VESALIUS-CV Randomized Clinical Trial

BACKGROUND: Evolocumab, a PCSK9 (proprotein convertase subtilisin–kexin type 9) inhibitor, significantly reduced the risk of cardiovascular events in patients without previous myocardial infarction or stroke in the VESALIUS-CV trial (Effect of Evolocumab in Patients at High Cardi...

Cannabinoids modulate inflammatory tone and attenuate inflammatory responses in human placental explants

Abstract Background With increasing cannabis use during pregnancy, understanding how cannabinoids affect placental immune function is fundamental. The placenta maintains a regulated immune environment through innate immune pathways, including nuclear factor kappa B (NF-κB)–depend...

Clinicopathological Characteristics and Outcomes of Primary Parotid Gland Carcinomas in the Czech Republic: a Multicenter Retrospective Cohort Study of 453 Surgically Treated Patients

Parotid gland carcinomas are rare malignancies with marked histological and biological heterogeneity. Most published evidence is derived from single-center or selected institutional series, whereas comprehensive nationwide epidemiological data remain limited. The aim of this stud...