University Hospital Brno

Longitudinal white matter changes in anorexia nervosa: an exploratory fixel-based study

Abstract Background This longitudinal study examined fiber-specific white matter (WM) changes in young women with restrictive-type anorexia nervosa (AN) during hospitalization and six months after discharge. Using advanced diffusion MRI methods, we aimed to characterize longitudi...

Multimodal Combination Treatment in a Patient-Centered Approach is Associated with Improved Outcome in Relapsed/Refractory Sarcomas in Children: A Comparative Single-Institution Real-World Analysis

Targeted treatment in children, especially with sarcomas, has limited utility due to small numbers of patients with driving mutations. Multimodal combination treatment and patient-centered approach combine treatment modalities administered based on comprehensive biological and em...

Delivery of cardiac rehabilitation through hybrid models and alternative settings by country income classification and decade: Comparisons from the International Council of Cardiovascular Prevention and Rehabilitation’s 2025 Global Audit Update

Objective Cardiac rehabilitation (CR) is an outpatient model of secondary prevention that improves patient outcomes, yet use remains limited. Hybrid/alternative CR addresses these challenges, but global availability, structure, and volumes have not been characterized since the pa...

A multicenter, prospective – retrospective, epidemiological study in Czech and Slovak minors with spinal muscular atrophy treated with nusinersen

Abstract Background We used the Czech REaDY registry to collect and analyse data of paediatric patients with spinal muscular atrophy (SMA) who received nusinersen for five years. By sharing the results, we aim to increase healthcare professionals’ knowledge about this therapy. Re...

Spinal-Multiple-Myeloma-SEG: A Dual-Energy CT Dataset Extended with Trabecular Bone Segmentation of Lumbar Vertebrae

We present an extension of the publicly available Spinal-Multiple-Myeloma-SEG dataset, a dual-energy CT imaging resource for multiple myeloma research. The purpose of this dataset is to enable voxel-wise analysis of vertebral bone microstructure by adding expert-validated segment...

Past and present phage therapy research and practice in the Czech Republic – contribution to phage therapy in Europe

Renewed interest in bacteriophage therapy, driven by the global rise of antimicrobial resistance, is accelerating efforts to establish its rational, evidence-based use in clinical practice. This review provides a comprehensive overview of the historical milestones, current status...

Musculoskeletal pain in healthcare workers in Slovakia: a nationwide cross-sectional observational study

The main objective of our study is to examine the prevalence of musculoskeletal pain among healthcare workers in Slovakia. The cross-sectional study analyzed a sample of 801 healthcare professionals, including physiotherapists, nurses, paramedics, and medical doctors. Data collec...

Hemorrhage Volume and Imaging Recommendations: Factors for Decision Making in the Care of Patients With Perimesencephalic Subarachnoid Hemorrhage

BACKGROUND AND OBJECTIVES: Perimesencephalic subarachnoid hemorrhage (pmSAH) has a markedly better prognosis than aneurysmal subarachnoid hemorrhage. Despite advances in noninvasive imaging, the role of repeat digital subtraction angiography (DSA) after negative initial high-qual...