University College Hospital

Invited submission to Reproduction and Fertility for “Evolving Perspectives in Management of Menopause Transition” Series

Abstract Menopause following cancer treatment is an increasingly recognised component of survivorship yet remains under-addressed in clinical care. The aim of this review is to synthesise current evidence on menopause induced by cancer treatment, by bringing together current evid...

HLA-B*27-associated arthritis across the ages – bridging the gap

HLA-B*27-associated arthritis comprises a number of different forms of inflammatory arthritis with a common phenotype, encompassed by the term spondyloarthritis. The clinical features and outcomes differ across the age spectrum which has resulted in different classification syste...

Validating the biological origin of in vivo fractional intracellular volume from VERDICT-MRI in the prostate

Abstract Objective Noninvasive microstructure estimates using magnetic resonance imaging (MRI) show potential in improving prostate cancer (PCa) diagnosis; however, histological validation is necessary. Materials and methods We used data from the Histo-MRI trial (NCT04792138). Pa...

Temporal trends in intraoperative hypotension exposure in major non-cardiac surgery: a retrospective cohort analysis

Abstract Background Intraoperative hypotension is a common occurrence during general anaesthesia that has consistently been associated with perioperative organ injury. While international consensus guidelines increasingly advocate for maintaining absolute mean arterial pressure t...

Blood-based biomarkers of Alzheimer’s disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms

Background: In low- and middle-income countries, Alzheimer's disease and related dementias (ADRD) constitute a growing public health burden. Indeed, the lack of awareness and easy screening tools, such as blood-based biomarkers, leaves many patients undiagnosed. In this study, we...

A prospective double-blinded randomized controlled trial comparing conventional jig-based versus robotic arm-assisted medial unicompartmental knee arthroplasty

Aims This study reports the interim outcomes of a randomized controlled trial comparing the accuracy of component positions, early functional outcomes, patient-reported outcome measures, and complications in conventional jig-based unicompartmental knee arthroplasty with navigatio...

National multi-specialty robotic surgery training curriculum and implementation for UK surgical residents: a delphi consensus

Abstract Robotic-assisted surgery is now established across multiple surgical specialties in the United Kingdom, yet training for surgical residents remains variable, resource-dependent, and insufficiently standardised at national level. This study sought multispecialty expert co...