University College Hospital

Diagnosing periprosthetic joint infection: current and novel technologies

IntroductionPeriprosthetic joint infection (PJI) remains a devastating complication of arthroplasty, afecting 1% to 2% of cases, and increasing with procedural volume. 1 Activity based analysis estimates a two-year cost of $64,585 (£31,322) per case. 2 Accurate diagnosis is essen...

Intraoperative hemoadsorption and postoperative inflammatory biomarkers in patients undergoing cardiac surgery, a meta-analysis of randomized controlled trials

Abstract Aim We aimed to perform a meta-analysis to evaluate the effect of intraoperative hemoadsorption (HA) with cardiopulmonary bypass (CPB) on postoperative inflammatory biomarkers in patients undergoing cardiac surgery. Methods We searched PubMed, Web of Science, and Scopus...

Diaphyseal zonal fixation in revision total knee arthroplasty

The concept of zonal fixation for the distal femur and proximal tibia has revolutionized our understanding of how to best achieve durable fixation in revision total knee arthroplasty. However, the diaphyseal zone covers most of the femur, and achieving durable diaphyseal fixation...

MRI-derived prostate volume assessment: manual segmentation versus two-axis ellipsoid approximation and its implications for PSA density

Abstract Purpose To evaluate how accurately prostate volume estimated with the ellipsoid formula matches manual segmentation (reference standard) and to assess whether an individualized, volume-dependent adjustment of the ellipsoid weighting factor improves performance. Methods I...

An Interactive Database of ADAMTS13 Variants Yields Novel Insight into Thrombotic Thrombocytopenic Purpura

Congenital thrombotic thrombocytopenic purpura (cTTP) is caused by pathogenic variants in ADAMTS13. Despite the continual expansion of genetic data, there remains no comprehensive, accessible database of ADAMTS13 variation available for clinicians and researchers. We performed a...

Systematic Review and Meta‐Analysis Suggested That Neutrophils Predominated the Airways of Children With the Respiratory Syncytial Virus

ABSTRACT Aim The respiratory syncytial virus (RSV) is a predominant aetiology of early‐life respiratory infections. This systematic review and meta‐analysis compared the cell types involved in airways inflammation in children with and without RSV, noting that immune responses can...

Invited submission to Reproduction and Fertility for “Evolving Perspectives in Management of Menopause Transition” Series

Abstract Menopause following cancer treatment is an increasingly recognised component of survivorship yet remains under-addressed in clinical care. The aim of this review is to synthesise current evidence on menopause induced by cancer treatment, by bringing together current evid...

HLA-B*27-associated arthritis across the ages – bridging the gap

HLA-B*27-associated arthritis comprises a number of different forms of inflammatory arthritis with a common phenotype, encompassed by the term spondyloarthritis. The clinical features and outcomes differ across the age spectrum which has resulted in different classification syste...

Validating the biological origin of in vivo fractional intracellular volume from VERDICT-MRI in the prostate

Abstract Objective Noninvasive microstructure estimates using magnetic resonance imaging (MRI) show potential in improving prostate cancer (PCa) diagnosis; however, histological validation is necessary. Materials and methods We used data from the Histo-MRI trial (NCT04792138). Pa...

Temporal trends in intraoperative hypotension exposure in major non-cardiac surgery: a retrospective cohort analysis

Abstract Background Intraoperative hypotension is a common occurrence during general anaesthesia that has consistently been associated with perioperative organ injury. While international consensus guidelines increasingly advocate for maintaining absolute mean arterial pressure t...

Blood-based biomarkers of Alzheimer’s disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms

Background: In low- and middle-income countries, Alzheimer's disease and related dementias (ADRD) constitute a growing public health burden. Indeed, the lack of awareness and easy screening tools, such as blood-based biomarkers, leaves many patients undiagnosed. In this study, we...

A prospective double-blinded randomized controlled trial comparing conventional jig-based versus robotic arm-assisted medial unicompartmental knee arthroplasty

Aims This study reports the interim outcomes of a randomized controlled trial comparing the accuracy of component positions, early functional outcomes, patient-reported outcome measures, and complications in conventional jig-based unicompartmental knee arthroplasty with navigatio...

National multi-specialty robotic surgery training curriculum and implementation for UK surgical residents: a delphi consensus

Abstract Robotic-assisted surgery is now established across multiple surgical specialties in the United Kingdom, yet training for surgical residents remains variable, resource-dependent, and insufficiently standardised at national level. This study sought multispecialty expert co...