University College Birmingham

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

Self‐Assembly of a Colloidal Honeycomb Crystal in Silico for Topological Valley Photonics

The quest to employ colloidal self-assembly as a scalable means of fabricating photonic crystals with a complete photonic band gap at optical frequencies has proved challenging throughout the first quarter of the 21st century. Meanwhile, the field of topological photonics has eme...

Gestational Changes in Placental Iron Homeostasis are Associated With Ferroptosis‐Associated Redox Signaling and Trophoblast Behavior

Well-regulated trophoblast proliferation, migration, invasion, and cell turnover are essential for normal placental development in humans and rodents. Given the established role of oxidative stress in placentation and the redox activity of iron, we investigated whether ferroptosi...

High Strength Steel Fatigue Crack Growth Database for Offshore Renewable Energy Applications

ABSTRACT High strength steels can reduce costs and carbon emissions in offshore renewable energy, but their effect on structural integrity remains unclear. In welded structures, such as support structures for offshore wind and tidal turbines, fatigue life is dominated by crack gr...

On-Surface Molecular Design and Synthesis of Discrete Metal–Fullerene Complexes on Graphite

Abstract On-surface synthesis enables the fabrication of molecular complexes, which cannot be obtained through traditional solution chemistry. Generally, metal substrates have been used due to their catalytic properties. Here, a tripod-like magnetic molecular complex, (C60)3–Co,...

The interplay of social capital, digital transformation and sustainability for designing international marketing strategies: a systematic literature review

Purpose This study systematically reviews the current literature on the role of social capital in adopting digital technologies and achieving sustainability. The current investigation identifies key insights across social capital, digital transformation and sustainability paradig...

Prevention and Management of Tooth Discolouration of Endodontic Origin ( DEO ): A State‐of‐the‐Art Review

ABSTRACT Background Tooth discolouration of endodontic origin (DEO) refers to an undesirable change in tooth colour arising from the pulp space as a result of reactive physiological processes, pathological processes or endodontic procedures and materials. As DEO frequently affect...

Improving the management of leprosy ulcers through a community self-care intervention using a stepped wedge cluster randomised trial in South-East Nigeria

Background Self-care is used to promote leprosy ulcer healing and reduce recurrence. RedAid Nigeria in South-East Nigeria adapted and implemented a recently developed international guideline for self-care of leprosy ulcers. We report a prospective, mixed methods evaluation of thi...

Bio-interfacial engineering of electrophoretic coacervate microcapsules for cytocompatible on-skin displays

Electrophoretic ink (e-ink) holds significant potential for energy-efficient displays and sustainable alternatives to print media. However, their use in wearables is hindered by hazardous materials which are cytotoxic and sensitizing to human tissue. While commercial e-inks encap...

CD248/Endosialin regulates synovial fibroblast state to control coupling of inflammation and bone damage in murine models of immune‐mediated inflammatory arthritis and ageing

Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/Endosialin is expressed by fibroblasts in the synovium, is highly upregulated during inflammation and has been proposed as a potential therapeutic target...

Rituximab therapy achieves comparable remission to cyclophosphamide in ANCA-associated vasculitis with severe KIDNEY involvement

Abstract Introduction The RAVE/RITUXIVAS trials established rituximab (RTX) therapy in ANCA-associated vasculitis (AAV). However, RAVE excluded patients with severe renal involvement (creatinine > 354 µmol/L). Whilst RITUXIVAS did not, treatment included RTX with 2 cyclophosphami...

Mast cells enhance venous thrombus stability and lung fibrin deposition in murine sepsis.

Venous thrombo-embolism is a serious complication of sepsis despite standard thromboprophylaxis. Mast cells (MCs) promote deep vein thrombosis (DVT) in sterile murine models, but their contribution during sepsis remains unknown. We explored the role of MCs in DVT in lipopolysacch...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

Stakeholder agency in humanitarian projects addressing forced displacement

Purpose Humanitarian projects address critical global issues such as poverty, climate change and forced displacement. However, research reveals that many such projects yield limited results when managed through a top-bottom approach. In this research, we investigate how the agenc...

Dawn of the dinosaurs demonstrates early diversification bursts and a potential role for neutral dynamics during major evolutionary radiations

Abstract Major radiations have given rise to huge swathes of life on Earth, and understanding their dynamics reveals the process of biodiversity generation itself. The rise of dinosaurs and other archosaurs during the Triassic was a spectacular example of such a radiation; it set...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

Consumers’ asset monetization: A conceptual framework and research agenda

Abstract This conceptual work investigates the emerging role of consumers as investors in various physical and digital assets. We introduce the notion of consumers’ asset monetization, defined as consumers’ orientation to monetize their asset(s) in secondary markets and benefit f...

Introducing Mid‐Level Dental Providers in Iran: Challenges and Opportunities

ABSTRACT Objectives The WHO Global Strategy and Action Plan on Oral Health 2023–2030 encourages innovative approaches such as shifting tasks from dentists to Mid‐level Dental Providers (MLDPs), who work independently to improve access to and equity in oral health. This study aime...

Fragmentalist Molinism

Abstract The Grounding Objection alleges that Molinist counterfactuals of creaturely freedom (CCFs) lack prevolitional truthmakers, while a related Alternative Possibilities Objection maintains that any determinate prevolitional basis for such ‘would’-facts threatens the alternat...