University Children's Hospital Zurich

Microsurgical Lymphovenous Anastomosis for the Treatment of Central Lymphatic Flow Disorders in Children and Adults

Central lymphatic flow disorders remain a significant diagnostic and therapeutic challenge. Treatment typically follows a stepwise escalation approach, with reconstructive surgery being employed mainly in patients in whom conservative and interventional methods have failed or are...

Interim Update on Reactive Infectious Mucocutaneous Eruption ( RIME )

ABSTRACT Reactive infectious mucocutaneous eruption (RIME), a term describing blistering skin and mucosal lesions, is a term coined by a group of Pediatric Dermatology Research Alliance (PeDRA) researchers and first published in 2021. Since that time, the literature has grown wit...

Rare LRRFIP1 variants contribute to pathophysiology of severe early-onset scoliosis and common scoliotic phenotypes

Despite enormous advances in clinical genomics, idiopathic scoliosis remains an enigmatic condition with poorly understood genetic and pathophysiological underpinnings impeding molecular diagnosis and the development of targeted treatments. We performed linkage analysis, exome, g...

Promotion of long-term health in early life

Noncommunicable chronic diseases (NCDs) are on the rise in high-income countries, leading to substantial morbidity and mortality and contributing to increased resource demands and healthcare costs. Early-life exposures can initiate trajectories that culminate in NCDs later in lif...

Advancing minimally invasive precision surgery in large open cavities with robotic flexible endoscopy

Flexible robots hold great promise for enhancing minimally invasive surgery (MIS) by providing superior dexterity, precise control, and safe tissue interaction. Yet, translating these advantages into endoscopic interventions in large open cavities remains challenging. The lack of...

Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review

Purpose Improved survival from critical illness has produced a growing population of intensive care unit (ICU) survivors with new or worsened physical, cognitive, and mental-health impairment, defined as post-intensive care syndrome (PICS), and frequent distress among families/ca...

Transcriptomic signatures of hydroxyurea response in sickle cell disease

Abstract Background Hydroxyurea (HU) has been widely used as a first-line therapy for sickle cell disease (SCD), an autosomal recessive monogenic disorder characterized by abnormal haemoglobin and chronic haemolysis. However, its multiple mechanisms of action, particularly those...

Between myopathy and mortality: Challenges in the diagnosis of PLOD1 -related kyphoscoliotic Ehlers-Danlos syndrome

Objective PLOD1-related kyphoscoliotic Ehlers-Danlos syndrome (kEDS) is a rare autosomal recessive connective tissue disorder characterized by generalized joint laxity, severe congenital hypotonia, progressive kyphoscoliosis, hyperextensible and easily bruised skin, ocular abnorm...

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...