University Children's Hospital Tübingen

Outcomes of front-line tagraxofusp in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) in a real-world scenario

Abstract Tagraxofusp (TAG), a CD123-directed protein-drug conjugate, is approved in front-line and relapsed/refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN). Multicenter real-world outcomes and the contribution of up-front consolidation post-TAG remain less defined...

Clinical management of metachromatic leukodystrophy cases identified in the German and Austrian Newborn screening pilots

Abstract Background Metachromatic leukodystrophy (MLD) is a rapidly progressive leukodystrophy that leads to severe disability and early death if untreated. Autologous hematopoietic stem and progenitor cell gene therapy (HSPC-GT, atidarsagene autotemcel, arsa-cel) for early onset...

Insulin Resistance in the 21st Century: New Takes on an Old Problem—2025 Diabetes , Diabetes Care , and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

Effect of prehospital cervical spine immobilization on mortality and neurological outcome in trauma patients: an observational cohort study with propensity score matching based on the trauma registry of the German trauma society (TraumaRegister DGU®)

Abstract Background Prehospital cervical spine immobilization is standard trauma care intended to prevent secondary spinal cord injury, yet evidence for its effectiveness is limited, and adverse effects are increasingly recognized. Large registry-based comparisons accounting for...

p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell

More than four decades after its discovery, p53 remains a central regulator of cellular homeostasis and one of the most extensively studied proteins in cancer biology [...]

Systemic administration of the mGluR2/3 antagonist LY341495 disrupts reward-related behaviors across ingestive and social domains in mice

Metabotropic glutamate 2/3 receptors (mGluR2/3) have been implicated in depression, anxiety, learning, and memory, yet their role in reward-related behavior remains poorly understood. Here, we examined the effects of the selective mGluR2/3 antagonist LY341495 on reward-related be...

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

Musculoskeletal ultrasonography of lower extremity entheses in children and adolescents - a pilot study of normal B-mode and Doppler characteristics

Abstract Background Musculoskeletal ultrasonography is an important imaging modality in children. Features of arthritis are well defined and age-related normative data exist. Data on entheses are limited with no consensus on definition of pathology. Objectives The aim of this pil...

Aberrant Expression of Multiple T‐Cell Markers in Primary Cutaneous Follicle Center Lymphoma: A Rare Case Report

ABSTRACT Aberrant expression of T‐cell markers in B‐cell lymphomas is rare and can pose diagnostic challenges. We report a case of a 65‐year‐old man presenting with newly developed scalp nodules. Histopathology revealed nodular lymphoid infiltrates composed of large centrocytes a...

eGDR and gastrointestinal cancer mortality in the UK Biobank: a prospective cohort study

Abstract Background This study examined the associations of estimated glucose disposal rate (eGDR), a surrogate of insulin sensitivity, and the insulin resistance indices TG/HDL-C and TyG with gastrointestinal (GI) cancer mortality in the UK Biobank. Methods We included 369,447 p...

Correlation of [18F]SiTATE-PET-tracer with somatostatin receptor expression in meningiomas: an exploratory ex vivo histological pilot study

Abstract Background Radioactively labeled somatostatin analogs (SSAs) are used in PET imaging of meningiomas due to the high expression of somatostatin receptor (SSTR) subtype 2. 18 F-labeled SSTR-tracers offer several economic and logistical advantages over 68 Ga-labeled tracers...

9.4‐Tesla magnetic resonance imaging in focal epilepsy patients with high‐resolution surface‐based profiling of focal cortical dysplasias

Abstract Objective The detection of subtle epileptogenic lesions such as focal cortical dysplasias (FCDs) is a clinical challenge in the management of drug‐resistant focal epilepsy (DRFE). Ultra‐high‐field (UHF) magnetic resonance imaging (MRI) offers increased signal‐to‐noise ra...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

On the blind spot: ethical conflicts of health care professionals in addressing opioid diversion - a template study protocol for multinational qualitative research

Abstract Background Opioid diversion—the unauthorized redirection of prescription opioids—is a growing global concern with significant public health implications. While diversion can occur at many points in the supply chain, instances involving healthcare professionals (HCPs) are...

Accurate quantification of spliced and unspliced transcripts for single-cell RNA sequencing with tidesurf

Abstract Motivation Single-cell RNA sequencing (scRNA-seq) allows for the detailed analysis of dynamic cellular processes. In particular, this has been enabled by the estimation of RNA velocity, the derivative of gene expression, from separate count matrices for different splice...

Durable clinical and immunologic response to an off-the-shelf EWSR1–FLI1 peptide vaccine in metastatic Ewing sarcoma

Abstract Ewing sarcoma is a rare, fusion-driven malignancy with poor prognosis in the metastatic setting, for which no established immunotherapeutic treatment is currently available. Fusion breakpoints are rational precision immunotherapy targets, yet clinical evidence of immunog...

Identification and phenotypic profiling of subgroups with distinct cognitive aging trajectories

Cognitive aging is shaped by genetic variation, environmental factors, and health-related conditions. Until now, it is largely unclear why some individuals maintain their cognitive function, and others show progressive cognitive decline. This study uncovered determinants of disti...

Quantifying the Interplay Between PRAME Expression and Classical Morphology: A Multivariable Analysis of 954 Suspected Melanocytic Lesions

The integration of immunohistochemical biomarkers like PRAME (Preferentially Expressed Antigen in Melanoma) into the histomorphological assessment of melanocytic lesions is gaining prominence. While PRAME’s diagnostic value is widely recognized, its independent weight compared di...