University Children’s Hospital Basel

Persistent lower urinary tract symptoms as an underrecognized presentation of posterior urethral valves

Abstract Background Posterior urethral valves (PUV) are the main cause of lower urinary tract obstruction in boys. Although usually detected prenatally or in early infancy, up to 25% of cases are diagnosed later in childhood [1]. The aim of this study is to examine the associatio...

Incidence and Risk Factors of Late‐Onset Hypoglycemia in Extremely Low Gestational Age or Extremely Low Birth Weight Infants

ABSTRACT Aim To determine incidence and risk factors associated with late‐onset hypoglycemia in extremely preterm or extremely low birth weight infants. Methods Retrospective single‐center cohort study including infants with a gestational age < 28 weeks or birth weight < 1000 g....

CAF-mediated immune exclusion in osteosarcoma: mechanisms, translational vulnerabilities, and therapeutic strategies

Abstract Background Osteosarcoma remains a highly aggressive bone malignancy with limited therapeutic progress in metastatic and treatment-refractory disease. Beyond tumor-intrinsic drivers, the tumor microenvironment has emerged as a critical determinant of immune escape, therap...

Adverse health outcomes across the life course in individuals with six rare bone diseases: a 10-year population-based cohort study

Abstract Background Rare bone diseases comprise a heterogeneous group of complex and disabling conditions. Evidence on age-specific hospitalization patterns and in-hospital outcomes across multiple rare bone diseases is limited. Methods Population-based cohort study using nationa...

Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging

To date, the identity and maintenance of postnatal thymic epithelial progenitor cells (TEPCs) remain unclear, as does the persistence of bipotent TEPCs after birth or whether lineage-restricted progenitors independently maintain separate TEC compartments. Using an inducible linea...