Universities of Giessen and Marburg Lung Center

Awareness of textual constructedness: Readerly responses to multimodality in post-postmodernist fictions of the digital

This article addresses textual constructedness as a particular kind of foregrounding and focuses on the question of how readers deal with multimodality in post-postmodernist fictions of the digital (PPFDs). PPFDs are contemporary print fictions that imitate, incorporate and/or ut...

Systemic Hypertension and Survival in Pulmonary Hypertension

Importance Pulmonary hypertension (PH), a progressive and life-threatening condition with rising prevalence among older adults, frequently coexists with systemic hypertension, the prognostic impact of which is poorly understood. Objective To evaluate the association between syste...

Common barriers and facilitators to the implementation of digital medicine in chronic respiratory diseases: a systematic review of reviews

Background and research question Digital Medicine offers significant potential for improving care in Respiratory Medicine, yet its full uptake remains limited. Barriers and facilitators involve multiple stakeholders and are likely shared across diseases and technologies. This stu...

Multimodal Machine Learning–Based Prediction of Relapse in Major Depressive Disorder

Importance Early identification of patients at high risk of relapse is key to personalized preventive strategies in major depressive disorder (MDD). However, current predictive models do not adequately account for the multimodal factors contributing to MDD relapse and fail to pro...

Targeting biglycan–TLR2/TLR4 interaction with synthetic peptides mitigates inflammation and ameliorates renal function in ischemia–reperfusion injury

Renal ischemia–reperfusion injury (IRI), characterized by enhanced inflammation, is a leading cause of acute kidney injury (AKI) with limited treatments beyond supportive dialysis. Biglycan through toll-like receptors (TLR)2/TLR4 signaling aggravates tissue damage in acute renal...

The lung microbiome in childhood-onset severe neuromuscular disease with respiratory insufficiency: rationale, current evidence, and opportunities for oxford nanopore long-read sequencing

Abstract In severe childhood-onset neuromuscular disease (NMD), ventilatory muscle weakness and ineffective airway clearance drive recurrent infections and chronic colonization that is often culture-negative, polymicrobial, or both. The lung microbiome framework offers a unifying...

Maternal metformin treatment in obese pregnant dams normalizes neonatal sensory-motor reflexes

BACKGROUND: Maternal overweight and obesity have reached epidemic proportions over recent decades, with detrimental effects on offspring metabolism and neurodevelopment. Metformin, commonly used to treat type 2 diabetes mellitus and gestational diabetes, is being investigated for...

The added value of echocardiography in pulmonary arterial hypertension risk assessment an artificial intelligence machine learning–derived analysis of the ULTRA RIGHT VALUE registry

Abstract Aims The right ventricle (RV) is a major determinant of outcome in pulmonary arterial hypertension (PAH), but its assessment has not been completely incorporated in the risk of mortality scores. We therefore evaluated the added value of echocardiography of the RV to risk...

Cyclosporin A triggers a RIG-I-mediated interferon response through multiple cellular processes

Abstract The development of broad-spectrum antiviral agents is essential for preparedness against emerging viruses with pandemic potential. Cyclosporin A (CsA), a clinically approved immunosuppressant, has been shown to exert antiviral activity against a wide range of viruses. Re...

Immunogenicity and safety of seasonal influenza vaccine co-administered with other vaccines: a systematic review and meta-analysis

Abstract Seasonal influenza remains a leading cause of global morbidity and mortality, highlighting the need for vaccination strategies that improve coverage and streamline vaccine delivery. In this systematic review and meta-analysis, we searched PubMed, Embase, Web of Science,...

Functional mapping and engineering of the Sec translocon unlocked by a cell-free system

Abstract Almost all proteins are inserted or translocated across membranes by the universally conserved Sec translocon. Despite its central role, experimental access to Sec function has remained limited. Here, we present a cell-free protein synthesis platform that inserts SecYEG...

Thalamocortical network dynamics can explain visual impulse responses and perceptual echoes

Although temporal information is ubiquitous in natural vision, the cortex shows strong intrinsic rhythmicity. Recent electroencephalogram (EEG) studies have revealed a component of the visual impulse response function (IRF) resembling a narrow alpha-band (7–13 Hz) filter with a s...