Universiti Malaysia Sarawak

Oxindole-pyrrole-piperazine hybrids as novel α-glucosidase inhibitors: Design, synthesis and evaluation

α-Glucosidase acts as one therapeutic target for diabetes. For finding novel α-glucosidase inhibitors, oxindole-pyrrole-piperazine hybrids ( OPP-1∼24 ) were synthesized. Inhibition evaluation revealed that all hybrids ( OPP-1∼X24 ) demonstrated potent α-glucosidase inhibitory act...

State ownership as a moderator of the ESG and financial performance relationship in Chinese listed steel companies

This paper uses 134 A-share listed steel companies in China from 2014 to 2023 (804 firm-year observations) as research subjects. The primary research question asks whether state ownership moderates the association between ESG performance and accounting-based financial performance...

Extraction and optimization of chitosan yield and deacetylation quality from mushroom mycelium waste

The growing mushroom industry generates substantial quantities of residual mycelial biomass, much of which is discarded despite its potential as a source of value-added biopolymers. This study investigated the extraction of fungal chitosan from Pleurotus ostreatus mycelium waste...

Agro-waste reinforced kombucha bacterial cellulose composites for sustainable woven craft materials

The global woven craft and material industry has faced increasing criticism for excessive water consumption, chemical pollution, microplastic release from synthetic fibres, and dependence on non-renewable petroleum-based resources. Kombucha bacterial cellulose (KBC), a biodegrada...

Decentralised Community-Based Hub-Intermediary-Spoke Model for Rapid Cardiac Ultrasound Triage for Early Heart Failure Detection: Findings From the Heart2Miss Initiative

Abstract Aims To evaluate the feasibility and system-level performance of Heart2Miss, a decentralised community-based triage model deploying AI-powered point-of-care ultrasound (AI-POCUS) via a hub-intermediary-spoke approach in diabetes primary care for early heart-failure (HF)...

A new genus and species of hagfish from Vietnam: A transitional lineage between Rubicundinae and Myxininae (Craniata: Myxiniformes)

Abstract Dolichostomus leucotaenia gen. et sp. nov. is described from two specimens collected from off northern Vietnam. It is characterized by a long, oval mouth opening visible from the ventral view, a feature unique among the order Myxiniformes. It also possesses a single medi...