Université Paris Sciences et Lettres

Experimental mineralogical replacement to investigate the role of texture on interface morphology, reaction kinetics and pore-scale transport during metasomatism

Dolomitization is a key diagenetic process that reorganizes porosity and permeability in carbonate rocks, yet the coupling between interface kinetics and transport heterogeneity remains poorly constrained. We performed time-resolved hydrothermal dolomitization (metasomatism) expe...

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

The adenylate cyclase toxin (CyaA) from Bordetella pertussis intoxicates host cells by directly translocating its N-terminal catalytic domain across the plasma membrane; however, the forces driving this unique process remain poorly defined. Here, we dissect the membrane transloca...

Critical neuronal avalanches arise from excitation-inhibition balanced spontaneous activity

Neuronal avalanches are sequences of neural activations exhibiting scale-invariant statistics, indicative of critical dynamics. Theoretical studies proposed that the balance between excitation (E) and inhibition (I), along with neuromodulation, are key factors influencing this cr...

A dendritic cell autophagy–neutrophil axis limits intratumoral STING immunotherapy

The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway promotes tumor immunogenicity, but intratumoral STING agonists, despite strong preclinical efficacy, have shown limited clinical efficacy. The mechanisms restricting therapeutic STING activation rem...

Thermohaline gradients and frontal regimes in the northwestern Tropical Atlantic

Abstract. At the edge of the Amazon River plume, stirring by the North Brazil Current (NBC) and its eddies creates sharp surface thermohaline gradients on scales of O(1–100) km. This study provides a comprehensive picture of these gradients and fronts associated with the region's...

On the Schubert calculus of the quantum K-theory for partial flag manifolds: a 3d A-model perspective

A bstract We further investigate the 3d gauged linear sigma model (GLSM)/ quantum K-theory correspondence for partial flag manifolds X ≡ Fl( k ; n ). This is a 3d uplift of the 2d GLSM/quantum cohomology correspondence with the 3d theory compactified on $$ {\mathbb{R}}^2\times {S...

Phonon thermal Hall effect in quartz and its absence in silica

The observation of a misalignment between the applied heat flux and the measured temperature gradient in insulating solids induced by magnetic field has become a subject of experimental investigation, theoretical speculation, and unsettled controversy. To identify the origin of t...

Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus

Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular pro...

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs

About 50 years after their development, the benzimidazole anthelmintic drugs still occupy a key role in the treatment of parasitic diseases. Like other anti-infective drugs, their extensive use has led to resistance development and now requires new solutions to treat these diseas...

Validation and Spin of the Bright Part of Gaia DR2 and DR3

ABSTRACT The Gaia Data Release 3 (DR3) is an important step in the realization of the future Gaia reference frame. Ideally, across G magnitudes from 3 to 21, the Gaia DR2 and DR3 objects with their positions (, ) and proper motions (, ) should be expressed in a nonrotating refere...

Seasonal dependence of temperate forest soil respiration to soil temperature and water content clarified through data-driven modeling

Soil respiration is commonly modelled as a function of soil temperature and soil moisture, without explicitly accounting for seasonal effects. We have therefore developed a data-driven model that integrates interactions among soil temperature, soil moisture, and seasonality. This...

PercolationMechanisms in Transient Polymer Networksacross Dilute and Semidilute Regimes

Abstract Percolation in transient polymer networks remains poorly understood because reversible cross-links continuously reorganize the network structure. In this study, we investigated percolation in transient polymer networks by independently controlling network connectivity an...

CRISPR screens reveal MCT1-driven metabolic escape from SMAD3 inhibition as a therapeutic vulnerability

Resistance to therapy remains a critical challenge in cancer. This is exemplified by TGF-β pathway inhibitors which, despite broad clinical testing, have failed to deliver survival benefit. More precise SMAD3 targeting has shown preclinical promise, yet resistance mechanisms to S...

Topologically Engineered DNA Origami: Responsive Locking of DNA Quadrilateral for Biosensing Application

Abstract DNA nanotechnology offers unique opportunities for creating various accurate and responsive nanostructures. Nevertheless, large-scale conformational changes with high geometric precision and efficiency remain major challenges. Herein we report a topologically engineered...

FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors

Fibroblast growth factor receptor 3 ( FGFR3 ) is one of the most frequently altered genes in bladder cancer, primarily through activating mutations that drive oncogenesis and are enriched in luminal tumors. However, the underlying gene regulatory network (GRN) remains poorly char...