Université Paris-Est Créteil

Impact of chronic doxycycline treatment in a mouse model of tauopathy

Tauopathies are neurodegenerative disorders characterized by the accumulation of hyperphosphorylated tau, leading to synaptic dysfunction, neuroinflammation, and both cognitive and motor impairments. Doxycycline (Doxy), a tetracycline antibiotic commonly used to treat bacterial i...

Optimal Vaccination Strategies for a Heterogeneous SIS Model

Abstract. We study in a general mathematical framework the optimal allocation of vaccine in an heterogeneous population. We cast the problem of optimal vaccination as a biobjective minimization problem [Formula: see text], where [Formula: see text] and [Formula: see text] stand,...

Termites play a crucial role in forming major tropical soils: insights from a deep Ferralsol

Abstract Soil bioturbation is increasingly recognized as a key driver of pedogenesis in tropical ecosystems, influencing above- and below-ground biodiversity, nutrient cycling, and aggregate stability across different spatial and temporal scales. This ecological process may play...

Energy de-escalation as a pathway to sufficiency: perspectives from infrastructures in a university campus

This research examines energy sufficiency in the built environment, understood as the reduction of energy consumption through changes in social practices and infrastructures, among other factors, as a key objective for remaining within planetary boundaries.We draw insights from s...

The One-Dimensional Compressible Navier–Stokes Equations in Critical Regularity Spaces

Abstract. We are concerned with the barotropic compressible Navier–Stokes equations on the real line. Our primary goal is to establish the global well-posedness in a critical regularity framework in the case where the initial data are small perturbations of a stable constant stat...

Paclitaxel-loaded nanostructured lipid carriers surface-functionalized with N6L for pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies, with limited therapeutic options. Despite advances in chemotherapy, such as FOLFIRINOX and Abraxane® (nab-paclitaxel) combined with gemcitabine, these treatments show limited effic...

Agronomic and socio-economic assessments of the roles of earthworms and termite mounds in paddy fields

Bioturbation, the physical disturbance and mixing of soil layers caused by the activity of living organisms, such as earthworms and termites, plays a critical role in shaping soil structure, enhancing nutrient cycling, and regulating ecosystem dynamics. In paddy fields, earthworm...