Université de Poitiers

Recurrent PDGFRB-Mutations in the Epithelioid Variant of Fibrous Papules

Fibrous papule (FP) is a common benign dermal mesenchymal lesion presenting as a solitary, dome-shaped papule mostly located on the nose. The morphologic spectrum is broad, and a number of variants have been described, including hypercellular, clear cell, pigmented, pleomorphic,...

Association between the site of emergency care and patient-centered outcomes in patients with cancer: rationale and design of the French COVER cohort

Patients living with cancer now account for a substantial and growing share of emergency department (ED) visits and carry a high burden of hospitalization and in-hospital death. Their acute presentations are frequently multifactorial - driven by disease progression, treatment tox...

Guidelines for Decisions to Withhold or Withdraw Life-Sustaining Treatments (LST) in Adult ICU

OBJECTIVE: The French Society of Anaesthesia and Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) and the French Society of Physical Medicine and Rehabilitation (Société Française de Médecine Physique et de Réadaptation (SOFMER)) aimed at providing...

Linking geothermal reservoir and lithium distribution: A handheld spectroscopy approach on deep wells in the Upper Rhine Graben

The Upper Rhine Graben (URG) hosts a deep geothermal system characterized by fluid circulation within fractured reservoirs at the sedimentary-basement interface. This study investigates cuttings from two deep geothermal wells in the Strasbourg area to assess how reservoir heterog...

Subcutaneous isatuximab by on-body-injector plus bortezomib, lenalidomide, and dexamethasone in newly diagnosed transplant-ineligible multiple myeloma: ISASOCUT study

Isatuximab–bortezomib–lenalidomide–dexamethasone (Isa-VRd) has emerged as a standard of care for newly diagnosed multiple myeloma transplant-ineligible patients. A subcutaneous (SC) formulation of isatuximab delivered via an on-body injector (OBI) has been developed to facilitate...

Monitoring symptoms and performance in rehabilitation: Can we detect COPD exacerbation?

Background In patients with COPD, exacerbations mark disease progression, with significant reduction in quality of life and impact on mortality. Early detection is crucial to mitigate their consequences. The aim of this study was to investigate whether monitoring symptoms and exe...

Integrating Bulk and Molecular Analyses with PCA to Elucidate OM Dynamics in Treated Sludge: Insights for Sustainable Waste Management

Abstract Effective sludge treatment is essential for sustainable waste management, addressing environmental protection, public health, and resource recovery objectives. This study investigates the stabilization dynamics of five treated sludge products—raw thickened, digested, dri...

Craniometric evaluation of population affinity among South African subadults

Although standard craniometrics is typically regarded as the method of choice for estimating population affinity in adults, its application to subadults has received limited attention, despite potential population-specific signals demonstrated in cranial growth patterns. This stu...

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

Engineering Ultra‐Low Fe or Ni Loading in Polymer Derived SiCN(O) Fibre Mats: Exploring the Performance towards Alkaline OER

ABSTRACT In this study, Fe or Ni‐anchored silicon carbo(xy)nitride (SiCN(O)) fibre mats were synthesized via the polymer‐derived ceramics (PDC) approach to investigate their electrocatalytic performance toward alkaline OER. The resulting fibrous‐supported pre‐catalysts formed por...

Use of cardiac magnetic resonance imaging after hospitalization for acute heart failure: insights from the French nationwide OFICA-2 cohort

Abstract Background Cardiac magnetic resonance (CMR) has a central role in the management of patients with acute heart failure (AHF), but timely access remains heterogeneous. We investigated real-world CMR use in patients hospitalized for AHF and its associations with demographic...

Improving diabetes management in older adults with cancer: a quality improvement project to enhance monitoring during steroid-based systemic anti-cancer therapy

PURPOSE: Older adults undergoing systemic anti-cancer therapy (SACT) with steroids are at high risk of developing steroid-induced hyperglycaemia (SIH). However, monitoring and management remain inconsistent. This quality improvement project (QIP) involved developing and evaluatin...

LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial Infarction

Importance: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition is recommended as second- or third-line lipid-lowering therapy after myocardial infarction (MI), resulting in prolonged periods of inadequate low-density lipoprotein cholesterol (LDL-C) control. Whether...

Relationships between general practice residents’ level of reflection and their competencies development: results from a pilot cross-sectional study

Reflective practice is a cornerstone for developing professional competence. Despite its importance, the relationship between levels of reflection and competence remains underexplored in medical education. This association was described in trainee teachers. Along with initiating...

A multi-dimensional hybrid stochastic model for early and interpretable blockage detection in programming education

Abstract Detecting student difficulties in programming education is a critical challenge for instructors, a task further complicated by the rise of AI coding assistants that can obscure the learning process. While fine-grained interaction logs from development environments offer...

Effect of chronic high‐altitude hypoxia on retinal vascular phenotype, choroidal and retinal vasoreactivity in Peruvian highlanders

Abstract High‐altitude chronic hypoxia can induce excessive erythrocytosis (EE, defined as a haemoglobin concentration of ≥21 g/dL in men), leading to hyperviscosity and promoting endothelial dysfunction. We aimed to assess whether EE affects the retinal vascular phenotype and th...

Dehumanization and Socioeconomic Status: Replicating and Extending the Animalization of Low-SES Targets and the Mechanization of High-SES Targets

In three preregistered, high-powered studies, we replicated and extended findings on dehumanization based on socioeconomic status (SES), where low-SES groups are denied Human Uniqueness (animalization), and high-SES groups are denied Human Nature (mechanization). Study 1 ( N = 29...

Pilot study on the evaluation of efficacy, safety, and tolerability of colchicine combined with acetylsalicylic acid versus acetylsalicylic acid alone in the management of minor acute ischemic strokes

Objectives: Stroke constitutes a public health issue globally, with an increased risk of subsequent vascular events. Inflammation is a novel therapeutic target to mitigate this risk. Therefore, this study aimed to evaluate the efficacy, safety, and tolerability of colchicine comb...